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REVIEW article

Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 14 - 2023 | doi: 10.3389/fimmu.2023.1300378
This article is part of the Research Topic

Atopic Dermatitis: from Bench to Bedside

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Tryptophan, an Important Link in Regulating the Complex Network of Skin Immunology Response in Atopic Dermatitis

Yaxin Huang1 Lingna Chen1 Fuming Liu1 Xia Xiong1 Yongliang Ouyang2 Yongqiong Deng1*
  • 1The Affiliated Hospital of Southwest Medical University, China
  • 2Luzhou People's Hospital, China

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Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease, of which the pathogenesis is a complex interplay between genetics and environment. Although the exact mechanisms of the disease pathogenesis remain unclear, the immune dysregulation primarily involving the Th2 inflammatory pathway and accompanied with an imbalance of multiple immune cells is considered as one of the critical etiologies of AD. Tryptophan metabolism has long been firmly established as a key regulator of immune cells and then affect the occurrence and development of many immune and inflammatory diseases. But the relationship between tryptophan metabolism and the pathogenesis of AD has not been profoundly discussed throughout the literatures. Therefore, this review is conducted to discuss the relationship between tryptophan metabolism and the complex network of skin inflammatory response in AD, which is important to elucidate its complex pathophysiological mechanisms, and then lead to the development of new therapeutic strategies and drugs for the treatment of this frequently relapsing disease.

Keywords: atopic dermatitis, Tryptophan, Gut Microbiota, immunology response, Inflammation

Received: 05 Oct 2023; Accepted: 31 Dec 2023.

Copyright: © 2023 Huang, Chen, Liu, Xiong, Ouyang and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD. Yongqiong Deng, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China