Gut Microbiota and Sepsis and Sepsis-related Death: A Mendelian Randomization Investigation
Jiao Liu
Dechang Chen- 1Department of Critical Care Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China
- 2Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China
It is unclear what the causal relationship is between the gut microbiota and sepsis. Therefore, we employed MR to determine whether a causal link exists between the two.Methods: This study used publicly available GWAS summary data of gut microbiota, sepsis, sepsis (critical care), and sepsis (28-day death in critical care) to perform a two-sample MR analysis. To ensure the robustness of the results, we also conducted a sensitivity analysis.Results: For sepsis susceptibility, IVW estimates revealed Victivallales (OR= 0.86, 95%CI, 0.78-0.94, P = 0.0017) was protective against sepsis.While, Lentisphaerae (OR=0.89, 95% CI, 0.80-0.99),
Keywords: Gut Microbiota, Sepsis, sepsis-related death, causality, Mendelian randomization
Received: 24 Jul 2023;
Accepted: 02 Jan 2024.
Copyright: © 2024 Shang, Zhang, Qian, Huang, Li, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mx. Dechang Chen, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China