Osteomyelitis affected bone regeneration studies of Linezolid combined Strontium substituted hydroxyapatite-Bi polymeric composite Provisionally Accepted

Hua Li¹ Qi Du² Pei-Yu Guo¹ Yong-Tao Yi¹ Xi Li^1*

• ¹The First Affiliated Hospital of Kunming Medical University, China
• ²Kunming Medical University, China

The primary objective of the investigation is to rectify bacterial infections in bone (Osteomyelitis) and bone regeneration by utilizing antibiotic-loaded hydroxyapatite polymer composite. In this regard, the strontium (Sr) -substituted hydroxyapatite (mHAP) reinforced polymeric composites with linezolid (LNZ) were utilized for osteomyelitis-affected bone repair. The brittle nature of the mHAP ceramic has been overcome by reinforcing the polymers such as polyvinyl pyrrolidone (PVP) and poly(sodium 4-styrene sulfonate) (PSSS). The composite formation, crystallinity, surface morphology, and zeta potentials were investigated through FTIR, XRD, SEM, TEM, and DLS techniques. The particle size and zeta potential were observed and the zeta potential value of mHAP/PVP-PSSS and mHAP/PVP-PSSS/LNZ composites are -14.8 mV and -40.3 mV, respectively. The bioactive results with SBF are favorable for apatite formation and confirm the composite's biocompatible to new bone formation.The cell viability of human bone marrow mesenchymal stem cells (hBMSCs) and the gene expression analysis confirmed the osteogenesis potential of the prepared materials. Since the prepared composite has obtained potential results, these studies confirm that the prepared composite can release the antibiotic for the treatment of osteomyelitis-affected bone repair.