AUTHOR=Lovas András , Németh Márton Ferenc , Trásy Domonkos , Molnár Zsolt 

TITLE=Lung Recruitment Can Improve Oxygenation in Patients Ventilated in Continuous Positive Airway Pressure/Pressure Support Mode

JOURNAL=Frontiers in Medicine

VOLUME=2

YEAR=2015

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2015.00025

DOI=10.3389/fmed.2015.00025

ISSN=2296-858X

ABSTRACT=<sec id="ST1"><title>Background</title><p>Recruitment maneuvers are often used in critical care patients with hypoxemic respiratory failure. Although continuous positive airway pressure/pressure support (CPAP/PS) ventilation is a frequently used approach, but whether lung recruitment also improves oxygenation in spontaneously breathing patients has not been investigated yet. The primary objective was to analyze the effect of recruitment maneuver on oxygenation in patients ventilated in CPAP/PS mode.</p></sec><sec id="ST2"><title>Methods</title><p>Following baseline measurements PEEP was increased by 5 cmH<sub>2</sub>O. Recruitment maneuver was applied for 40 s with 40 cmH<sub>2</sub>O of PS. Measurements of the difference in PaO<sub>2</sub>/FiO<sub>2</sub> and airway parameters measured by the ventilator were recorded immediately after recruitment then 15 and 30 min later. Thirty patients ventilated in CPAP/PS mode with a PEEP ≥5 cmH<sub>2</sub>O were enrolled in this prospective, observational study if their PaO<sub>2</sub>/FiO<sub>2</sub> ratio was &lt;300 mmHg or required an FiO<sub>2</sub> &gt;0.5.</p></sec><sec id="ST3"><title>Results</title><p>Following recruitment maneuver patients were considered as non-responders (NR, <italic>n</italic> = 15) if difference of PaO<sub>2</sub>/FiO<sub>2</sub> &lt;20% and responders (R, <italic>n</italic> = 15) if difference of PaO<sub>2</sub>/FiO<sub>2</sub> ≥20%. In the NR-group, PaO<sub>2</sub>/FiO<sub>2</sub> decreased non-significantly from baseline: median [interquartile], PaO<sub>2</sub>/FiO<sub>2</sub> = 176 [120–186] vs. after recruitment: 169 [121–182] mmHg, <italic>P</italic> = 0.307 while in the R-group there was significant improvement: 139 [117–164] vs. 230 [211–323] mmHg, <italic>P</italic> = 0.01. At the same time points, dead space to tidal volume ratio (Vds/Vte) significantly increased in the NR-group Vds/Vte = 32 [27–37] vs. 36 [25–42]%, <italic>P</italic> = 0.013 but no significant change was observed in the R-group: 26 [22–34] vs. 27 [24–33]%, <italic>P</italic> = 0.386.</p></sec><sec id="ST4"><title>Conclusion</title><p>Recruitment maneuver improved PaO<sub>2</sub>/FiO<sub>2</sub> ratio by ≥20% in 50% of patients ventilated in CPAP/PS mode.</p></sec>