AUTHOR=Roche Magali , Wierinckx Anne , Croze Séverine , Rey Catherine , Legras-Lachuer Catherine , Morel Anne-Pierre , Fusco Alfredo , Raverot Gérald , Trouillas Jacqueline , Lachuer Joel TITLE=Deregulation of miR-183 and KIAA0101 in Aggressive and Malignant Pituitary Tumors JOURNAL=Frontiers in Medicine VOLUME=2 YEAR=2015 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2015.00054 DOI=10.3389/fmed.2015.00054 ISSN=2296-858X ABSTRACT=
Changes in microRNAs (miRNAs) expression in many types of cancer suggest that they may be involved in crucial steps during tumor progression. Indeed, miRNAs deregulation has been described in pituitary tumorigenesis, but few studies have described their role in pituitary tumor progression toward aggressiveness and malignancy. To assess the role of miRNAs within the hierarchical cascade of events in prolactin (PRL) tumors during progression, we used an integrative genomic approach to associate clinical–pathological features, global miRNA expression, and transcriptomic profiles of the same human tumors. We describe the specific down-regulation of one principal miRNA, miR-183, in the 8 aggressive (A, grade 2b) compared to the 18 non-aggressive (NA, grades 1a, 2a) PRL tumors. We demonstrate that it acts as an anti-proliferative gene by directly targeting