Editorial: Innovative Radiopharmaceuticals in Oncology and Neurology

Editorial on the Research Topic Innovative Radiopharmaceuticals in Oncology and Neurology Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therapies and targeted radionuclide therapy provides efficacious treatment modalities against cancer. An incredible amount of innovation is related to the use of a variety of radionuclides, new or improved multimodality imaging devices, and numbers of recently marketed radiopharmaceuticals in all medical domains and particularly cardiology, neurology, and oncology. In this context, a network of laboratories and Nuclear Medicine departments, the IRON Laboratory of Excellence (Labex), has been set as part of the French " Investissements d' Avenir " program to help translating innovative radiopharmaceuticals into clinical testing by a multidisciplinary approach from the production of radionuclides using cyclotrons, to basic studies of targets and ligands, clinical trials, and assessment of the societal impacts of innovation in medicine in neurology and oncology. To foster communication between scientists, inside the Labex and with the international community, a series of highly specialized international " Nuclear Technologies for Health Symposia " has been organized annually, with the most recent edition, the third, held in Nantes, France, on March 10–11, 2015. Plenary lectures given by distinguished speakers (Hank Kung, Philadelphia, PA, USA, Tom Back, Gothenburg, Sweden, Otto Boerman, Nijmegen, The Netherlands, Franck Bruchertseifer, Karlsruhe, Germany, and Claire Tabouret-Viaud, Geneva, Switzerland) addressed the state of the arts and new developments in the use of radioactivity and radiopharmaceuticals for multimodality imaging and therapy. The latest achievements in clinical nuclear medicine, science, and technology were discussed during interactive oral and poster sessions. Selected talks were organized in four sessions: innovative tracers in neurology: from bench to bedside, multimodality imaging, theranostic in nuclear medicine, and targeted radionuclide therapy. After the meeting, 12 papers were published in the Nuclear Medicine topic open by Frontiers in Medicine. These papers are representative of current research and development in Nuclear Medicine.


Innovative Radiopharmaceuticals in Oncology and Neurology
Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therapies and targeted radionuclide therapy provides efficacious treatment modalities against cancer. An incredible amount of innovation is related to the use of a variety of radionuclides, new or improved multimodality imaging devices, and numbers of recently marketed radiopharmaceuticals in all medical domains and particularly cardiology, neurology, and oncology.
In this context, a network of laboratories and Nuclear Medicine departments, the IRON Laboratory of Excellence (Labex), has been set as part of the French "Investissements d' Avenir" program to help translating innovative radiopharmaceuticals into clinical testing by a multidisciplinary approach from the production of radionuclides using cyclotrons, to basic studies of targets and ligands, clinical trials, and assessment of the societal impacts of innovation in medicine in neurology and oncology. To foster communication between scientists, inside the Labex and with the international community, a series of highly specialized international "Nuclear Technologies for Health Symposia" has been organized annually, with the most recent edition, the third, held in Nantes, France, on March 10-11, 2015.
Plenary lectures given by distinguished speakers (Hank Kung, Philadelphia, PA, USA, Tom Bäck, Gothenburg, Sweden, Otto Boerman, Nijmegen, The Netherlands, Franck Bruchertseifer, Karlsruhe, Germany, and Claire Tabouret-Viaud, Geneva, Switzerland) addressed the state of the arts and new developments in the use of radioactivity and radiopharmaceuticals for multimodality imaging and therapy. The latest achievements in clinical nuclear medicine, science, and technology were discussed during interactive oral and poster sessions.
Selected talks were organized in four sessions: innovative tracers in neurology: from bench to bedside, multimodality imaging, theranostic in nuclear medicine, and targeted radionuclide therapy.
After the meeting, 12 papers were published in the Nuclear Medicine topic open by Frontiers in Medicine. These papers are representative of current research and development in Nuclear Medicine.
In a review article, Chatal et al. discussed the interest of 82 Rb PET for heart diseases, especially in obese patients and in women with large breasts. A great advantage of 82 Rb PET is its capacity to accurately measure myocardial blood flow and coronary reserve. 82 Rb has a very short half-life (75 sec) and is obtained from an 82 Sr/ 82 Rb generator. A major limitation for this technology is the low worldwide production of 82 Sr, but the situation is improving with new production facilities, including Arronax, becoming active, increased production yields, and approval of new generator/infuser systems.
Another radionuclide that attracts interest is 64 Cu, a PET emitter with a longer half-life (12.7 h). 64 Cu may be used to label peptides and antibodies. Another potential application is the mapping of tumor hypoxia using 64 Cu-ATSM, as discussed by Colombié et al. Hypoxic cells are more resistant to chemotherapy and to external beam radiation therapy. Delivering increased radiation doses to tumor hypoxic areas delineated by PET imaging could improve response. However, there is some controversy about the actual cause of increased 64 Cu-ATSM in tumor tissues. Nuclear Medicine is also therapy. This has been known for many years, with the use of 131 I in the treatment of thyroid cancer. Tracking other cancers remains a challenge, but progress is made. New radioactive therapeutic agents are designed to improve response and survival, while minimizing side-effects. Locoregional injection of radioactive microparticles is in use in hepatic cancers. Encapsulation of radionuclides in nanoparticles that could be injected systemically has been proposed as a way to increase the radioactive load and reduce exposure of normal tissues. Lepareur and coworkers described non-toxic nanoparticles, able to release their load in a controlled way. They prepared biodegradable and biocompatible pegylated nanoparticles loaded with a lipophilic 99m Tc-labeled tracer that may be labeled by 188 Re for therapy (Lepareur et al.). Targeting similar nanoparticles is also explored by Rauscher et al., who develop pegylated liposomes labeled with 111 In and 125/131 I for pretargeted radioimmunotherapy, using a bispecific monoclonal antibody recognizing a tumor antigen and a small molecular weight tag attached to the surface of the liposomes. Immunospecific tumor targeting was demonstrated in vitro and in vivo in a mouse model.
With small radiolabeled molecules, clinical proofs of concept have been obtained for a variety of pretargeting methods in single photon imaging, PET imaging, and therapy. The key is the bispecific pretargeting agent and the optimization of the pretargeting protocol. Bodet-Milin et al. studied a new class of bispecific antibodies in a phase I radioimmunotherapy trial (http://ClinicalTrials.gov NCT01221675) to optimize pretargeting parameters. The best dosing parameters were a short pretargeting delay (24 h) and a high bispecific molar dose.
A promising avenue for cancer therapy is the use of alphaparticle emitters. Alpha particles have very short tracks (usually less than 100 µm) and a very high cytotoxic potential even against radioresistant tumor cells in hypoxic area. 223 Ra, a bone targeting agent, has been recently approved for symptomatic metastatic prostate cancer therapy. Antibodies may be used to target other alpha-emitting radionuclides. Here, 213 Bi has been targeted to multiple myeloma, in a syngeneic mouse model, by means of an anti-CD138 antibody. Fichou et al. demonstrated that 213 Bi is much more effective than 177 Lu. The higher efficacy in such disseminated diseases has been presented as the major interest and the best rationale for the use of alpha emitters in therapy, but this is one of the first direct comparisons. In the same model, Gorin et al. showed that autophagy is a prominent cell death mechanism with 213 Bi. Derrien et al. confirmed the efficacy of locally delivered antibodies labeled with 213 Bi in an ovarian cancer model and proposed combination with hyperthermic intraperitoneal chemotherapy in an attempt to treat advanced disease.