TY - JOUR AU - Ma, Cheryl Ann AU - Leung, Ying Ying PY - 2017 M3 - Review TI - Exploring the Link between Uric Acid and Osteoarthritis JO - Frontiers in Medicine UR - https://www.frontiersin.org/articles/10.3389/fmed.2017.00225 VL - 4 SN - 2296-858X N2 - Both gout and osteoarthritis (OA) are common forms of arthritis that inflict a huge burden to an aging population with the increasing prevalence of obesity. Clinicians have long observed the link between these two conditions. In this review, we summarize the evidence from epidemiologic and immunological studies that described the possible relationship between the two conditions. The recent new understanding on monosodium uric acid crystal-induced inflammation has given insight into probable shared pathogenesis pathways for both conditions. We describe the potential therapeutic implications, particularly regarding the possibility of repurposing traditional gout medications for use in OA. ER -