@ARTICLE{10.3389/fmed.2018.00335, AUTHOR={Bonnet, Anne-Laure and Chaussain, Catherine and Broutin, Isabelle and Rochefort, Gaël Y. and Schrewe, Heinrich and Gaucher, Céline}, TITLE={From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?}, JOURNAL={Frontiers in Medicine}, VOLUME={5}, YEAR={2018}, URL={https://www.frontiersin.org/articles/10.3389/fmed.2018.00335}, DOI={10.3389/fmed.2018.00335}, ISSN={2296-858X}, ABSTRACT={First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.} }