%A Liao,Xuejiao %A Liu,Jiaye %A He,Ziyi %A Hu,Ming %A Xiao,Tongyang %A Wei,Lanlan %A Cai,Qiue %A Wang,Haiyan %A He,Qing %A Liu,Lei %A Zhang,Zheng %D 2020 %J Frontiers in Medicine %C %F %G English %K Coronavirus disease 2019 (COVID-19),Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),pediatric,antibody,Clinical features %Q %R 10.3389/fmed.2020.579406 %W %L %M %P %7 %8 2020-November-04 %9 Original Research %# %! Longitudinal clinical features with COVID-19 %* %< %T Longitudinal Changes on Clinical Features in 28 Children With COVID-19 in Shenzhen, China %U https://www.frontiersin.org/articles/10.3389/fmed.2020.579406 %V 7 %0 JOURNAL ARTICLE %@ 2296-858X %X Objective: To investigate the clinical characteristics of children with coronavirus disease 2019 (COVID-19) and identify the occurrence of viral shedding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during follow-up.Methods: We retrospectively retrieved data from pediatric patients with COVID-19 from the Shenzhen Third People's Hospital in China. The dynamics of SARS-CoV-2 and antibodies against SARS-CoV-2 were analyzed during hospitalization and after discharge.Results: From January 23 to March 15, 2020, a total of 28 pediatric patients were diagnosed with COVID-19 and were followed for at least 1 month. The median age was 7 years (IQR 3.5–10) and none of the children progressed to severe COVID-19 during hospitalization. Ten patients tested positive for SARS-CoV-2 1 month after discharge while four patients tested positive during the 2nd month after discharge. Only three of 12 children showed detectable immunoglobulin-M (IgM) on day 5, 18, and 21 after illness onset, respectively.Conclusions: COVID-19 disease was relatively mild among children while a number did test positive after discharge from the hospital. Public health initiatives should thus adapt control measures targeted toward children.