AUTHOR=Stanculescu Dominic , Larsson Lars , Bergquist Jonas 

TITLE=Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.628029

DOI=10.3389/fmed.2021.628029

ISSN=2296-858X

ABSTRACT=<p>Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression of the pituitary gland's <italic>pulsatile</italic> secretion of tropic hormones, and (b) a “vicious circle” between inflammation, oxidative and nitrosative stress (O&amp;NS), and low thyroid hormone <italic>function</italic>. This hypothesis should be investigated through collaborative research projects.</p>