AUTHOR=Garcez Patricia P. , Guasti André , Ventura Nina , Higa Luiza Mendonça , Andreiuolo Felipe , de Freitas Gabriella Pinheiro A. , Ribeiro Liane de Jesus , Maia Richard Araújo , de Lima Sheila Maria Barbosa , de Souza Azevedo Adriana , Schwarcz Waleska Dias , Caride Elena Cristina , Chimelli Leila , Dubois Luiz Gustavo , Ferreira Júnior Orlando da Costa , Tanuri Amilcar , Moura-Neto Vivaldo , Niemeyer Paulo TITLE=Case report: Regression of Glioblastoma after flavivirus infection JOURNAL=Frontiers in Medicine VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1192070 DOI=10.3389/fmed.2023.1192070 ISSN=2296-858X ABSTRACT=

Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.