Skip to main content


Front. Med.
Sec. Gene and Cell Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1329981

Effects of Aerobic Exercise Training on Intestinal Flora Structure in Female Drug Addicts Provisionally Accepted

  • 1Yunnan Normal University, China
  • 2Women's Compulsory Isolation and Drug Rehabilitation Institutions, China
  • 3Drug Rehabilitation Administration of the Ministry of Justice of the People’s Republic of China, China

The final, formatted version of the article will be published soon.

Receive an email when it is updated
You just subscribed to receive the final version of the article

Purpose:Purpose: This study aimed to investigate the effect of aerobic exercise on the gut microbiota structure of female drug addicts. A total of 100 female students from a compulsory drug rehabilitation center in Yunnan Province, China, were recruited into the study and assigned to the traditional drug groups or the new-type drug group, depending on the type of drug-taking. Next, based on whether they underwent the training protocol or not, the participants were randomly split into two control groups (the traditional drug control group [BC] and the new drug control group [BX]) and two exercise intervention groups (the exercise intervention traditional drug group [MC] and the exercise intervention new drug group [MX]), 25 participants per group. The exercise group received treadmill training for 12 weeks, while the control group maintained regular daily routines. Fecal samples were collected pre- and post-training and analyzed via high-throughput sequencing to study the effect of exercise on the gut microbiota of drug addicts. Results: 12 weeks of aerobic exercise can improve gut microbial diversity and increase beneficial bacteria. OTUs counts in exercise groups increased compared to control groups. The OTU count of the MC group increased significantly. After the exercise intervention, principal component analysis revealed the following results: (1) at the phylum level, the dominant taxa, mainly composed of the phyla Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria, did not change significantly, suggesting that the composition of the gut microbiota may not be affected by exercise; (2) at the family or order levels, the MC group exhibited significantly higher abundance of Enterobacteriaceae and Enterobacterales when compared with the BC group (P < 0.05). At the order level, when compared with the BX group, the MX group had a significantly higher abundance of Atopobiaceae, Porphyromonadaceae, Pasteurellaceae, and Pasteurellales (P<0.05); (3) at the genus level, exercise significantly increased the abundance of Prevotella and Roseburia in the MC group when compared with the BC group (P<0.05). The abundance of Escherichia-Shigella and Megamonas was significantly lower in the MX group than in the BX group (P<0.05). In summary, these beneficial bacteria can be targeted for microbiota intervention in female drug addicts.

Keywords: intestinal flora, 16srRNA, drug addiction, aerobic exercise, gut health

Received: 30 Oct 2023; Accepted: 23 Jan 2024.

Copyright: © 2024 Wang, Lei, Yuan, Yuan, Shen and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Hang p. Wang, Yunnan Normal University, Kunming, China