TY - JOUR AU - Stach, James AU - Good, Liam PY - 2011 M3 - Review TI - Synthetic RNA Silencing in Bacteria – Antimicrobial Discovery and Resistance Breaking JO - Frontiers in Microbiology UR - https://www.frontiersin.org/articles/10.3389/fmicb.2011.00185 VL - 2 SN - 1664-302X N2 - The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the “antibiotic miracle.” Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved target selection, evaluation, and screening. Furthermore, we focus on synthetic RNA silencers as a novel class of antibacterials and review their unique properties. ER -