AUTHOR=Stach James, Good Liam TITLE=Synthetic RNA Silencing in Bacteria – Antimicrobial Discovery and Resistance Breaking JOURNAL=Frontiers in Microbiology VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/articles/10.3389/fmicb.2011.00185 DOI=10.3389/fmicb.2011.00185 ISSN=1664-302X ABSTRACT=The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the “antibiotic miracle.” Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved target selection, evaluation, and screening. Furthermore, we focus on synthetic RNA silencers as a novel class of antibacterials and review their unique properties.