AUTHOR=Green Keith , Garneau-Tsodikova Sylvie TITLE=Resistance in tuberculosis: what do we know and where can we go? JOURNAL=Frontiers in Microbiology VOLUME=4 YEAR=2013 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2013.00208 DOI=10.3389/fmicb.2013.00208 ISSN=1664-302X ABSTRACT=

Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.