@ARTICLE{10.3389/fmicb.2017.00242, AUTHOR={de Oliveira, Sandra R. P. and Nomizo, Auro and Frantz, Fabiani G. and Faccioli, Lúcia H. and Matos, Ana Paula Keller de and Carrilho, Emanuel and Afonso, Ana and de Freitas Anibal, Fernanda}, TITLE={Participation of Leukotrienes in the Immune Modulation of Oral Tolerance}, JOURNAL={Frontiers in Microbiology}, VOLUME={8}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fmicb.2017.00242}, DOI={10.3389/fmicb.2017.00242}, ISSN={1664-302X}, ABSTRACT={Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-γ in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-γ remains being secreted, which gives us an indication of immune system specificity and also that IFN-γ participates in various immune processes.} }