%A Bradrick,Shelton S.
%D 2017
%J Frontiers in Microbiology
%C
%F
%G English
%K Methylation,Flavivirus,Zika virus,Dengue Virus,Hepatitis C virus
%Q
%R 10.3389/fmicb.2017.02374
%W
%L
%M
%P
%7
%8 2017-December-05
%9 Mini Review
%+ Shelton S. Bradrick,Department of Biochemistry and Molecular Biology, University of Texas Medical Branch,United States,sbrad001@gmail.com
%#
%! Flavivirus methylation
%*
%<
%T Causes and Consequences of Flavivirus RNA Methylation
%U https://www.frontiersin.org/articles/10.3389/fmicb.2017.02374
%V 8
%0 JOURNAL ARTICLE
%@ 1664-302X
%X Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5′ cap structure is essential for infection whereas 2′-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.