%A Bradrick,Shelton S. %D 2017 %J Frontiers in Microbiology %C %F %G English %K Methylation,Flavivirus,Zika virus,Dengue Virus,Hepatitis C virus %Q %R 10.3389/fmicb.2017.02374 %W %L %M %P %7 %8 2017-December-05 %9 Mini Review %+ Shelton S. Bradrick,Department of Biochemistry and Molecular Biology, University of Texas Medical Branch,United States,sbrad001@gmail.com %# %! Flavivirus methylation %* %< %T Causes and Consequences of Flavivirus RNA Methylation %U https://www.frontiersin.org/articles/10.3389/fmicb.2017.02374 %V 8 %0 JOURNAL ARTICLE %@ 1664-302X %X Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5′ cap structure is essential for infection whereas 2′-O-methylation of the penultimate nucleotide is required for evasion of host innate immunity. N6-methylation of internal adenosine nucleotides has also been shown to impact flavivirus infection. Here, I summarize recent progress made in understanding roles for methylation in the flavivirus life-cycle and discuss relevant emerging hypotheses.