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Front. Microbiol. | doi: 10.3389/fmicb.2018.00333

Phylogenomic based comparative studies on Indian and American commensal Staphylococcus epidermidis isolates

  • 1Institute of Microbial Technology (CSIR), India

Staphylococcus epidermidis is a prominent commensal member of human skin microbiome and an emerging nosocomial pathogen, making it a good model organism to provide genomic insights, correlating its transition between commensalism and pathogenicity. While there are numerous studies to understand differences in commensal and pathogenic isolates, systematic efforts to understand variation and evolutionary pattern in multiple strains isolated from healthy individuals are lacking. In the present study, using whole genome sequencing and analysis, we report presence of diverse lineages of S. epidermidis isolates in healthy individuals from two geographically diverse locations of India and North America. Further, there is distinct pattern in the distribution of candidate gene(s) for pathogenicity and commensalism. The pattern is not only reflected in lineages but is also based on geographic origin of the isolates. This is evident by the fact that North American isolates under this study are more genomically dynamic and harbor pathogenicity markers in higher frequency. On the other hand, isolates of Indian origin are less genomically dynamic, harbor less pathogenicity marker genes and possess two unique antimicrobial peptide gene clusters. This study provides a basis to understand the nature of selection pressure in a key human skin commensal bacterium with implications in its management as an opportunistic pathogen.

Keywords: phylogenetic, Genomics, Staphylococcus epidermidis, commensal, geographic, diverse, markers, pathogen, evolution, Phylogeography, phylogenomics

Received: 15 Nov 2017; Accepted: 12 Feb 2018.

Edited by:

Yasir Muhammad, King Abdulaziz University, Saudi Arabia

Reviewed by:

Sandip Paul, CSIR-IICB, India
Ben Pascoe, University of Bath, United Kingdom  

Copyright: © 2018 Sharma, Chaudhry, Kumar and Patil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Prabhu B. Patil, Institute of Microbial Technology (CSIR), Chandigarh, India,