%A He,Li-Hong %A Ren,Long-Fei %A Li,Jun-Feng %A Wu,Yong-Na %A Li,Xun %A Zhang,Lei %D 2020 %J Frontiers in Microbiology %C %F %G English %K COVID-19,Gut-Lung Axis,Immunity,intestinal flora,SARS-CoV-2,SCFAs %Q %R 10.3389/fmicb.2020.01388 %W %L %M %P %7 %8 2020-June-09 %9 Review %# %! Intestinal Flora and SARS-CoV-2 %* %< %T Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection %U https://www.frontiersin.org/articles/10.3389/fmicb.2020.01388 %V 11 %0 JOURNAL ARTICLE %@ 1664-302X %X The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the “gut-lung axis” has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.