AUTHOR=Liu Dong , Zeng Ying-Ying , Shi Meng-Meng , Qu Jie-Ming 

TITLE=Glucocorticoids Elevate Pseudomonas aeruginosa Binding to Airway Epithelium by Upregulating Syndecan-1 Expression

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.725483

DOI=10.3389/fmicb.2021.725483

ISSN=1664-302X

ABSTRACT=Glucocorticoids are commonly used for the treatment of asthma and chronic obstructive
pulmonary disease (COPD). Inhaled corticosteroids were associated with a significantly
increased risk of pneumonia. Syndecan-1 (SDC1) located in the cell membrane of airway
epithelial cell is the crucial molecular mediating infections by P. aeruginosa (PA).
In the present study, we found SDC1 expression was up regulated greatly and the
adhesion of PA to human bronchial cell line (HBE) increased to 125% and 138%
respectively after stimulation by dexamethasone or budesonide. The HBE cells knocking
down SDC1 showed lower affinity to PA compared with control. CCAAT-enhancer-binding
protein β (C/EBPβ) and its phosphorylated form participated in the regulation of
glucocorticoid to SDC1 for interfering C/EBPβ or inhibiting phosphorylation of C/EBPβ by
Licl and BIO, which are inhibitors of glycogen synthase kinase 3β (GSK-3β), could prevent
glucocorticoids to up regulate SDC1 expression.
Administrating glucocorticoids should be cautious in chronic lung disease for their property
of increasing the expression of SDC1 and PA binding to airway epithelium.