AUTHOR=Vinagre João , Borges Fátima , Costa António , Alvelos Maria Inês , Mazeto Glaúcia , Sobrinho-Simões Manuel , Soares Paula TITLE=Differentiated thyroid cancer in patients with resistance to thyroid hormone syndrome. A novel case and a review of the literature JOURNAL=Frontiers in Molecular Biosciences VOLUME=1 YEAR=2014 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2014.00010 DOI=10.3389/fmolb.2014.00010 ISSN=2296-889X ABSTRACT=
Resistance to thyroid hormone (RTH) represents a syndrome in which patients present elevated circulating thyroid hormones in the presence of non-suppressed TSH. We report a novel case where a patient with RTH presented a differentiated thyroid cancer. A19 year-old female had been referred due to thyroid disease that disclosed features characteristic of a RTH. During the follow up it was detected a follicular tumor that led to the recommendation for thyroid surgical ablation, where an incidental papillary thyroid microcarcinoma (mPTC) was found. The increase of thyroglobulin (TG) levels following thyroid removal referred the patient for radioiodine treatment. Post-treatment, it was detected jugular adenopathies and the patient was subjected to cervical lymph node drainage where metastases of the mPTC were found. RTH syndrome was confirmed by the detection of a