AUTHOR=Guan Huai , Song Shuaibao , Robinson Howard , Liang Jing , Ding Haizhen , Li Jianyong , Han Qian TITLE=Structural Basis of the Substrate Specificity and Enzyme Catalysis of a Papaver somniferum Tyrosine Decarboxylase JOURNAL=Frontiers in Molecular Biosciences VOLUME=4 YEAR=2017 URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2017.00005 DOI=10.3389/fmolb.2017.00005 ISSN=2296-889X ABSTRACT=
Tyrosine decarboxylase (TyDC), a type II pyridoxal 5′-phosphate decarboxylase, catalyzes the decarboxylation of tyrosine. Due to a generally high sequence identity to other aromatic amino acid decarboxylases (AAADs), primary sequence information is not enough to understand substrate specificities with structural information. In this study, we selected a typical TyDC from