AUTHOR=Poggi Maurizio, Samperi Irene, Mattia Lorenza, Di Rocco Arianna, Iorio Cristina, Monti Salvatore, Pugliese Giuseppe, Toscano Vincenzo TITLE=New Insights and Methods in the Approach to Thalassemia Major: The Lesson From the Case of Adrenal Insufficiency JOURNAL=Frontiers in Molecular Biosciences VOLUME=6 YEAR=2020 URL=https://www.frontiersin.org/articles/10.3389/fmolb.2019.00162 DOI=10.3389/fmolb.2019.00162 ISSN=2296-889X ABSTRACT=Background: Thalassemia Major (TM) is a complex pathology that needs a highly skilled approach. Endocrine comorbidities are nowadays the most important complications, including hypogonadism, hypothyroidism, diabetes mellitus, and bone diseases. Recent works stated that there could be a relevant prevalence of adrenal insufficiency (AI) present in TM, and this fact may become crucial, especially in case of major stressful events.Aim: Test the reliability of the standard test to diagnose AI in a group of TM and correlate it with clinical, hematological, and radiological data.Methods: We evaluated endocrine damages and the efficacy of iron chelation therapy in 102 patients affected by TM. AI was assessed by tetracosactide (Synacthen) 1 mcg iv (low-dose test, LDT) stimulation test. Patients with a subnormal response (peak cortisol < 500 nmol/L) were followed up to 5 years to check the symptoms and signs of AI.Results: We found AI in 13.7% of the population studied. We did not find any correlation between AI and all data evaluated. Only female gender seems to be a protective factor. A follow up of the patients affected by AI showed no signs of adrenal crisis, in spite of no replacement therapy.Conclusions: Our study shows a relevant prevalence of AI in TM, especially in males. The absence of an adrenal crisis, in spite of no replacement therapy, during the long-term follow up, seems to underline that current methods to evaluate AI, in TM, should consider a different and specific diagnostic test or different cut off for diagnosis.