AUTHOR=Yao Yihan , Zhou Yunxiang , Liu Lihong , Xu Yanyan , Chen Qiang , Wang Yali , Wu Shijie , Deng Yongchuan , Zhang Jianmin , Shao Anwen 

TITLE=Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 7 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2020.00193

DOI=10.3389/fmolb.2020.00193

ISSN=2296-889X

ABSTRACT=Nanotechnology has been extensively studied and exploited for cancer treatment as the important role of nanoparticles in drug delivery system. Compared with conventional drugs, nanoparticle-based drug delivery has specific advantages, including good stability, biocompatibility, enhancing permeability and retention effect and precise targeting. In addition, nanoparticle drugs have also shown a certain role in overcoming drug resistance of cancer. The application and development of hybrid nanoparticles with combined properties of different nanoparticles lead this type of drug-carrier system to a further step. In this review, we discuss the nanoparticles and hybrid nanoparticles for drug delivery, and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance.