Front. Mol. Biosci. Frontiers in Molecular Biosciences Front. Mol. Biosci. 2296-889X Frontiers Media S.A. 727347 10.3389/fmolb.2021.727347 Molecular Biosciences Correction Corrigendum: CORO1C is Associated with Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer Wang et al. Corrigendum: CORO1C in Colorectal Cancer Wang Zongxia 1 Jia Lizhou 1 2 Yushu sun 3 Li Chunli 1 Zhang Lingli 4 Wang Xiangcheng 5 6 * Chen Hao 2 7 * Cancer Center, Bayannur Hospital, Bayannur, China Department of Pathology, Wannan Medical College, Wuhu, China Department of Oncology, Inner Mongolia Autonomous Region Cancer Hospital, Hohhot, China Department of Ophthalmology, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, China Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China Key Laboratory of Inner Mongolia Autonomous Region Molecular Imaging, Inner Mongolia Medical University, Hohhot, China Faculty of Medical Science, Jinan University, Guangzhou, China

Edited by: Haishi Qiao, China Pharmaceutical University, China

Reviewed by: Ern Yu Tan, Tan Tock Seng Hospital, Singapore

 *Correspondence: Xiangcheng Wang, guyan@nmgfy.com; Hao Chen, ha0chen@wnmc.edu.cn

This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences

 30 08 2021 2021 8 727347 18 06 2021 14 07 2021 Copyright © 2021 Wang, Jia, Yushu sun, Li, Zhang, Wang and Chen. 2021 Wang, Jia, Yushu sun, Li, Zhang, Wang and Chen

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 A corrigendum on CORO1C is Associated with Poor Prognosis and Promotes Metastasis through PI3K/AKT Pathway in Colorectal Cancer by Wang, Z., Jia, L., Sun, Y., Li, C., Zhang, L., Wang, X., Chen, H. (2021). Front. Mol. Biosci. 8:682594. doi: 10.3389/fmolb.2021.682594 CORO1C colorectal cancer prognosis metastasis Akt

In the original article, there was a mistake in the caption for Figure 4A as published. The incorrect caption stated NCM460 cell lines are normal gastric epithelial cells, however, NCM460 cell lines are normal colorectal epithelial cells. The correct caption for Figure 4 appears below. Additionally, there was a mistake in Figure 1 as published. Figure 1C is immunofluorescence and Figure 1D is immunocomplex by Co-IP. OE-ControlTrop2 should appear on the top row and OE-Trop2 should appear on the bottom row in Figure 1C. Representative images for these parts contain small issues which have been corrected. The corrected Figure 1 appears below.

FIGURE 4. The effects of CORO1C knockdown on CRC growth and metastasis in vitro and in vivo. (A) Levels of CORO1C1 protein expression in CRC cell lines and normal colorectal epithelial cells (NCM460) determined by western blotting. (B) COCA2 and HCT116 cells showed a significant decrease in protein level after shCORO1C transfection. (C) CORO1C downregulation significantly inhibited the proliferation of both cell lines. (D) A significant decrease in cell anchorage-dependent growth was detected after CORO1C knockdown. (E, F) Decreased CORO1C expression impaired abilities of migration (E) and invasion (F) of CRC cells (scale bar, 150 μm). All quantitative data of in vitro assays were generated from three replicates (G). The effects of CORO1C downregulation on the tumor growth in the xenograft mouse model (n = 6 mice/per group). *p < 0.05, **p < 0.01, ***p < 0.001.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Associations between CORO1C, TROP2, and CRC metastasis. Overexpression of Trop2 in 293T cells was confirmed by (A) qRT-PCR, (B) Western blotting, and (C) Immunofluorescence. (D) Trop2 immunocomplex by Co-IP; (E) Heatmap of proteins interacting with Trop2 in PC and MC. The RNA-seq data were obtained from GSE28702. Red and green colors represent high and low gene expression, respectively. PC: primary CRC; MC: metastatic CRC, **p < 0.01.

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