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REVIEW article

Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1268019
This article is part of the Research Topic

Research on Stem Cell-derived Exosomes in Regenerative Medicine

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Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Skeletal Diseases Provisionally Accepted

Xiaobo Yang1 Shaodian Zhang1 Jinwei Lu1 Xiaoling Chen2 Chenyi Ye1 Jianbin Xu1*
  • 1Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, China
  • 2Fourth Affiliated Hospital, School of Medicine, Zhejiang University, China

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Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional therapies based on mesenchymal stem cells (MSCs) to exosomes derived from MSCs. Exosomes are natural nanocarriers of endogenous DNA, RNA, proteins, and lipids and have a low immune clearance rate and good barrier penetration and allow targeted delivery of therapeutics. MSC-derived exosomes (MSC-exosomes) have the characteristics of both MSCs and exosomes, and so they can have both immunosuppressive and tissue-regenerative effects. Despite advances in our knowledge of MSC-exosomes, their regulatory mechanisms and functionalities are unclear. Here we review the therapeutic potential of MSC-exosomes for skeletal diseases.

Keywords: MSC-exosomes, Skeletal disease, Osteoarthritis, Osteoporosis, Fracture

Received: 27 Jul 2023; Accepted: 16 May 2024.

Copyright: © 2024 Yang, Zhang, Lu, Chen, Ye and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Jianbin Xu, Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Jiangsu Province, China