TY - JOUR
AU - Elshehabi, Morad
AU - Maier, Katrin S.
AU - Hasmann, Sandra E.
AU - Nussbaum, Susanne
AU - Herbst, Heinz
AU - Heger, Tanja
AU - Berg, Daniela
AU - Hobert, Markus A.
AU - Maetzler, Walter
PY - 2016
M3 - Original Research
TI - Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson’s Disease during Single and Dual Tasking
JO - Frontiers in Aging Neuroscience
UR - https://www.frontiersin.org/articles/10.3389/fnagi.2016.00004
VL - 8
SN - 1663-4365
N2 - BackgroundIn Parkinson’s disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.MethodsThirty-nine early-to-moderate PD patients performed the following standardized ST and dual tasks as fast as possible for 1 min during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters as well as velocity of the secondary tasks were analyzed.ResultsThe following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p = 0.03); step duration (p = 0.048) and peak velocity (p = 0.04) during turning; velocity of checking boxes during ST (p = 0.04) and DT (p = 0.04). Velocity of checking boxes was the only parameter that also improved during DT.ConclusionThese results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early-to-moderate PD during DT.
ER -