AUTHOR=Grieb Pawel , Jünemann Anselm , Rekas Marek , Rejdak Robert 

TITLE=Citicoline: A Food Beneficial for Patients Suffering from or Threated with Glaucoma

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=8

YEAR=2016

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00073

DOI=10.3389/fnagi.2016.00073

ISSN=1663-4365

ABSTRACT=<p>Oral form of citicoline, a nootropic and neuroprotective drug in use for almost five decades, recently was pronounced a food supplement in both USA and EU. The idea of adding citicoline to topical treatment of primary open angle glaucoma (POAG) aimed at decreasing intraocular pressure (IOP) appeared as a logical consequence of accepting neurodegenerative character of this disease. Experimental data, and also few clinical studies indicate that this substance has potential to counteract some important pathological mechanisms which seem to contribute to POAG initiation and progression, such as excitotoxicity and oxidative stress.</p>