AUTHOR=Shibata Takashi , Musha Toshimitu , Kosugi Yukio , Kubo Michiya , Horie Yukio , Kuwayama Naoya , Kuroda Satoshi , Hayashi Karin , Kobayashi Yohei , Tanaka Mieko , Matsuzaki Haruyasu , Nemoto Kiyotaka , Asada Takashi 

TITLE=Altered Neuronal Activity Topography Markers in the Elderly with Increased Atherosclerosis

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=9

YEAR=2017

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2017.00216

DOI=10.3389/fnagi.2017.00216

ISSN=1663-4365

ABSTRACT=<p><bold>Background:</bold> Previously, we reported on vascular cognitive impairment (VCI) templates, consisting of patients with VCI associated with carotid stenosis (&gt;60%) using a quantitative electroencephalographic (EEG) technique called neuronal activity topography (NAT). Here using the VCI templates, we investigated the hypothesis that internal carotid artery–intima-media thickness (ICA–IMT) is associated with EEG spectrum intensity (sNAT) and spectrum steepness (vNAT).</p><p><bold>Methods:</bold> A total of 221 community-dwelling elderly subjects were recruited. Four groups were classified according to quartiles of ICA–IMT as assessed by ultrasonography: control group A, normal (≤0.9 mm); group B, mild atherosclerosis (1−1.1 mm); group C, moderate atherosclerosis (1.2−1.8 mm); and group D, severe atherosclerosis (≥1.9 mm). EEG markers of power ratio index (PRI), and the binary likelihood of being in the VCI group vs. the that of being in control group A (<italic>s</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub>, <italic>v</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub>) were assessed, respectively. Differences in mean total scores for PRI, <italic>s</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub>, <italic>v</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub>, between control group A and the other groups were compared using Dunnett's test, respectively.</p><p><bold>Results:</bold> The mean total scores of the PRI were 3.25, 3.00, 2.77, and 2.26 for groups A, B, C, and D, respectively. There was a significant decrease in the PRI in group D compared with group A (<italic>P</italic> = 0.0066). The mean total scores of the <italic>s</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub> were −0.14, −0.11, −0.1, and −0.03 for groups A, B, C, and D, respectively. The <italic>s</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub> in group D was significantly higher compared to that in group A (<italic>P</italic> &lt; 0.0001). The mean total scores of the <italic>v</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub> were −0.04,−0.01, 0.01, and 0.06 for group A, B, C, and D, respectively. The <italic>v</italic>L<sub><italic>x</italic>:<italic>VCI</italic>−<italic>A</italic></sub> in group D and group C was significantly higher compared to that in group A, respectively (<italic>P</italic> &lt; 0.0001, <italic>P</italic> = 0.02).</p><p><bold>Conclusion:</bold> Community-dwelling elderly subjects in the increased carotid atherosclerosis of ICA–IMT (≥1.9 mm) were at greatest risk of an EEG change as assessed by NAT.</p>