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Front. Aging Neurosci. | doi: 10.3389/fnagi.2018.00040

Depressive symptom dimensions and their association with hippocampal and entorhinal cortex volumes in community dwelling older adults

 Deirdre O'Shea1*,  Vonetta Dotson2,  Adam Woods1, 3, Eric Porges1, 3, John Williamson1,  Andrew O'Shea1, 3 and  Ronald Cohen3
  • 1University of Florida, United States
  • 2Georgia State University, United States
  • 3Department of Aging and Geriatric Research McNight Brain institute, University of Florida, United States

Objective: Research has shown that depression is a risk factor for Alzheimer’s disease (AD) and subsequent cognitive decline. This is compounded by evidence showing an association between depression and reduced hippocampal volumes; a primary structure implicated in the pathogenesis of the disease. Less is known about the relationship between depression and other AD vulnerable regions such as the entorhinal cortex. Given the heterogeneity of depressive symptom presentation, we examined whether symptom dimensions were associated with hippocampal and entorhinal cortex volumes in community dwelling older adults.
Methods: Eighty one community dwelling adults completed the Beck Depression Inventory – 2nd edition and underwent structural neuroimaging. Measures of hippocampal and entorhinal cortex volumes were using obtained FreeSurfer software. Linear regression models included regions of interest as dependent variables, with depressive symptom dimensions, as independent variables, controlling for total intracranial volumes, age, education and gender.
Results: Somatic symptoms were negatively associated with total, right and left hippocampal volumes. Affective symptoms were negatively associated with total entorhinal cortex volumes, with a marginal main effect on left entorhinal cortex volumes.
Conclusions: Our findings provide support for examining depressive symptoms and their association with AD vulnerable regions along sub-dimensions of affective, cognitive and somatic symptoms to better understand profiles of symptoms most associated with these regions. Conceptualizing depressive symptoms in this way may also better inform treatment approaches in terms of targeting types of symptoms that may be more closely linked to poorer brain and cognitive health outcomes.

Keywords: depressive symptom dimensions, Hippocampal volumes, entorhinal cortex volumes, Aging, older adults

Received: 03 Dec 2017; Accepted: 05 Feb 2018.

Edited by:

Aurel Popa-Wagner, Department of Neurology, University Hospital Essen, Germany

Reviewed by:

Gianluca Serafini, Dipartimento di Neuroscienze e Organi di Senso, Ospedale San Martino (IRCCS), Italy
Raluca Sandu Vintilescu, University of Medicine and Pharmacy of Craiova, Romania  

Copyright: © 2018 O'Shea, Dotson, Woods, Porges, Williamson, O'Shea and Cohen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ms. Deirdre O'Shea, University of Florida, Gainesville, United States, dmo2123@ufl.edu