@ARTICLE{10.3389/fnagi.2018.00057, AUTHOR={Arciniega, Hector and Gözenman, Filiz and Jones, Kevin T. and Stephens, Jaclyn A. and Berryhill, Marian E.}, TITLE={Frontoparietal tDCS Benefits Visual Working Memory in Older Adults With Low Working Memory Capacity}, JOURNAL={Frontiers in Aging Neuroscience}, VOLUME={10}, YEAR={2018}, URL={https://www.frontiersin.org/articles/10.3389/fnagi.2018.00057}, DOI={10.3389/fnagi.2018.00057}, ISSN={1663-4365}, ABSTRACT={Working memory (WM) permits maintenance of information over brief delays and is an essential executive function. Unfortunately, WM is subject to age-related decline. Some evidence supports the use of transcranial direct current stimulation (tDCS) to improve visual WM. A gap in knowledge is an understanding of the mechanism characterizing these tDCS linked effects. To address this gap, we compared the effects of two tDCS montages designed on visual working memory (VWM) performance. The bifrontal montage was designed to stimulate the heightened bilateral frontal activity observed in aging adults. The unilateral frontoparietal montage was designed to stimulate activation patterns observed in young adults. Participants completed three sessions (bilateral frontal, right frontoparietal, sham) of anodal tDCS (20 min, 2 mA). During stimulation, participants performed a visual long-term memory (LTM) control task and a visual WM task. There was no effect of tDCS on the LTM task. Participants receiving right unilateral tDCS showed a WM benefit. This pattern was most robust in older adults with low WM capacity. To address the concern that the key difference between the two tDCS montages could be tDCS over the posterior parietal cortex (PPC), we included new analyses from a previous study applying tDCS targeting the PPC paired with a recognition VWM task. No significant main effects were found. A subsequent experiment in young adults found no significant effect of either tDCS montage on either task. These data indicate that tDCS montage, age and WM capacity should be considered when designing tDCS protocols. We interpret these findings as suggestive that protocols designed to restore more youthful patterns of brain activity are superior to those that compensate for age-related changes.} }