%A Boccardi,Virginia %A Westman,Eric %A Pelini,Luca %A Lindberg,Olof %A Muehlboeck,J-Sebastian %A Simmons,Andrew %A Tarducci,Roberto %A Floridi,Piero %A Chiarini,Pietro %A Soininen,Hilkka %A Kloszewska,Iwona %A Tsolaki,Magda %A Vellas,Bruno %A Spenger,Christian %A Wahlund,Lars-Olof %A Lovestone,Simon %A Mecocci,Patrizia %D 2019 %J Frontiers in Aging Neuroscience %C %F %G English %K Ageing,Alzheimer’s disease,Mild Cognitive Impairment,Inflammation,Inflammatory markers %Q %R 10.3389/fnagi.2018.00439 %W %L %M %P %7 %8 2019-January-17 %9 Original Research %# %! IL-4 and hippocampal subfields in cognitive impairment %* %< %T Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease %U https://www.frontiersin.org/articles/10.3389/fnagi.2018.00439 %V 10 %0 JOURNAL ARTICLE %@ 1663-4365 %X Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD.Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.