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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00067

Loss of Parietal Memory Network Integrity in Alzheimer’s Disease

Yang Hu1,  Wenying Du2, Yiwen Zhang1,  Ying Han2* and  Zhi Yang1*
  • 1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, China
  • 2Xuanwu Hospital, Capital Medical University, China

A functional brain network, termed the parietal memory network (PMN), has been shown to reflect the familiarity of stimuli in both memory encoding and retrieval. The function of this network has been separated from the commonly investigated default mode network (DMN) in both resting-state fMRI and task-activations. This study examined the deficit of the PMN in AD patients using resting-state fMRI and independent component analysis, and investigated its diagnostic value in identifying AD patients. The DMN was also examined as a reference network. In addition, the robustness of the findings was examined using different types of analysis methods and parameters. Our results showed that the integrity as an intrinsic connectivity network for the PMN was significantly decreased in AD and this feature showed at least equivalent predictive ability to that for the DMN. These findings were robust to varied methods and parameters. Our findings suggest that the intrinsic connectivity of the PMN is disrupted in AD and further call for considering the PMN and the DMN separately in clinical neuroimaging studies.

Keywords: Alzheimer’s disease, Parietal memory network, Default Mode Network, Network integrity, Independent Component Analysis

Received: 01 Aug 2018; Accepted: 08 Mar 2019.

Edited by:

Lutz Jäncke, University of Zurich, Switzerland

Reviewed by:

Rui Li, Institute of Psychology, Chinese Academy of Sciences, China
Marina Weiler, National Institutes of Health (NIH), United States
Adrian Gilmore, National Institute of Mental Health (NIMH), United States  

Copyright: © 2019 Hu, Du, Zhang, Han and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Ying Han, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Beijing Municipality, China, hanying@xwh.ccmu.edu.cn
Dr. Zhi Yang, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai, 201108, China, yangz@smhc.org.cn