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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00228

New perspective for non-invasive brain stimulation site selection in mild cognitive impairment: based on the meta- and functional connectivity analyses

Jiao Liu1, Binlong Zhang1,  Georgia J. Wilson1 and  Jian Kong1*
  • 1Massachusetts General Hospital, Harvard Medical School, United States

Background: Non-invasive brain stimulation (NIBS) has been widely used to treat mild cognitive impairment (MCI). However, there exists no consensus on the best stimulation sites.

Objective: To explore potential stimulation locations for NIBS treatment in patients with MCI, combining meta- and resting state functional connectivity (rsFC) analyses.

Methods: The meta-analysis was conducted to identify brain regions associated with MCI. Regions of interest (ROIs) were extracted based on this meta-analysis. The rsFC analysis was applied to 45 MCI patients to determine brain surface regions that are functionally connected with the above ROIs.

Results: We found that the dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus were the overlapping brain regions between our results and those of previous studies. In addition, we recommend that the temporoparietal junction (including the angular gyrus), which was found in both the meta- and rsFC analysis, should be considered in NIBS treatment of MCI. Furthermore, the bilateral orbital prefrontal gyrus, inferior temporal gyrus, medial superior frontal gyrus, and right inferior occipital gyrus may be potential brain stimulation sites for NIBS treatment of MCI.

Conclusion: Our results provide several potential sites for NIBS, such as the DLFPC and inferior frontal gyrus, and may shed light on the locations of NIBS sites in the treatment of patients with MCI.

Keywords: Mild Cognitive Impairment, non-invasive brain stimulation, Stimulation site, Meta-analysis, resting state function connectivity

Received: 12 Apr 2019; Accepted: 09 Aug 2019.

Edited by:

Johannes Boltze, University of Warwick, United Kingdom

Reviewed by:

Ramesh Kandimalla, Texas Tech University Health Sciences Center, United States
Gabriel Gonzalez-Escamilla, University Medical Centre, Johannes Gutenberg University Mainz, Germany  

Copyright: © 2019 Liu, Zhang, Wilson and Kong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jian Kong, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, Massachusetts, United States,