%A Zhou,Zhike %A Zhong,Shanshan %A Liang,Yifan %A Zhang,Xiaoqian %A Zhang,Rongwei %A Kang,Kexin %A Qu,Huiling %A Xu,Ying %A Zhao,Chuansheng %A Zhao,Mei %D 2021 %J Frontiers in Aging Neuroscience %C %F %G English %K Uric Acid,Dementia,Alzheimer's disease,risk factor,Meta-analysis %Q %R 10.3389/fnagi.2021.625690 %W %L %M %P %7 %8 2021-February-25 %9 Systematic Review %# %! Meta-analysis of UA on dementia %* %< %T Serum Uric Acid and the Risk of Dementia: A Systematic Review and Meta-Analysis %U https://www.frontiersin.org/articles/10.3389/fnagi.2021.625690 %V 13 %0 JOURNAL ARTICLE %@ 1663-4365 %X Background: This meta-analysis aimed to evaluate the relationship between serum uric acid (UA) and the risk of dementia and its subtypes.Methods: Embase, PubMed, and Web of Science were searched from inception to July 2020. Random-effect models were employed to analyze the standard mean difference (SMD) with the corresponding 95% confidence intervals (CI).Results: Twenty-three eligible studies involving 5,575 participants were identified. The overall results showed lower levels of UA in dementia relative to non-dementia controls [SMD = −0.32 (−0.64; −0.01) p = 0.04]. The subgroup analysis of the type of dementia demonstrated a significant association of UA with Alzheimer's disease (AD) [SMD = −0.58 (−1.02; −0.15) p = 0.009] and Parkinson's disease with dementia (PDD) [SMD = −0.33 (−0.52; −0.14) p = 0.001] but not with vascular dementia (VaD). The stratification analysis of the concentrations of UA revealed that the UA quartile 1–2 was negatively correlated with dementia and neurodegenerative subtypes (p < 0.05), whereas a positive correlation of UA quartile 4 with dementia was noted (p = 0.028). Additionally, the meta-regression analysis on confounders showed that not age, body mass index, diabetes mellitus, hypertension, or smoking but education (p = 0.003) exerted an influence of the UA in the risk estimate of dementia.Conclusions: Low concentrations of UA (< 292 μmol/L or 4.91 mg/dL) is a potential risk factor for AD and PDD but not for VaD. The mechanism of different concentrations of the UA in dementia needs to be confirmed through further investigation.