AUTHOR=Tajiri Naoki , Acosta Sandra , Portillo-Gonzales Gabriel S. , Aguirre Daniela , Reyes Stephanny , Lozano Diego , Pabon Mibel , Dela Peña Ike , Ji Xunming , Yasuhara Takao , Date Isao , Solomita Marianna A. , Antonucci Ivana , Stuppia Liborio , Kaneko Yuji , Borlongan Cesar V. TITLE=Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke JOURNAL=Frontiers in Cellular Neuroscience VOLUME=8 YEAR=2014 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00227 DOI=10.3389/fncel.2014.00227 ISSN=1662-5102 ABSTRACT=

Accumulating preclinical evidence suggests the use of amnion as a source of stem cells for investigations of basic science concepts related to developmental cell biology, but also for stem cells’ therapeutic applications in treating human disorders. We previously reported isolation of viable rat amniotic fluid-derived stem (AFS) cells. Subsequently, we recently reported the therapeutic benefits of intravenous transplantation of AFS cells in a rodent model of ischemic stroke. Parallel lines of investigations have provided safety and efficacy of stem cell therapy for treating stroke and other neurological disorders. This review article highlights the need for investigations of mechanisms underlying AFS cells’ therapeutic benefits and discusses lab-to-clinic translational gating items in an effort to optimize the clinical application of the cell transplantation for stroke.