AUTHOR=Choi Su Yeon , Han Kihoon , Cutforth Tyler , Chung Woosuk , Park Haram , Lee Dongsoo , Kim Ryunhee , Kim Myeong-Heui , Choi Yeeun , Shen Kang , Kim Eunjoon TITLE=Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference JOURNAL=Frontiers in Cellular Neuroscience VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2015.00283 DOI=10.3389/fncel.2015.00283 ISSN=1662-5102 ABSTRACT=
Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (