@ARTICLE{10.3389/fncel.2017.00277, AUTHOR={Wyler, Steven C. and Lord, Caleb C. and Lee, Syann and Elmquist, Joel K. and Liu, Chen}, TITLE={Serotonergic Control of Metabolic Homeostasis}, JOURNAL={Frontiers in Cellular Neuroscience}, VOLUME={11}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fncel.2017.00277}, DOI={10.3389/fncel.2017.00277}, ISSN={1662-5102}, ABSTRACT={New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.} }