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Synaptic Loss and Neurodegeneration

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Front. Cell. Neurosci. | doi: 10.3389/fncel.2018.00473

The role of glial cells and synapse loss in mouse models of Alzheimer's disease

  • 1University Hospital Freiburg, Germany

Synapse loss has detrimental effects on cellular communication, leading to network disruptions within the central nervous system such as in Alzheimer´s disease (AD). AD is characterized by a progressive decline of memory function, cognition, neuronal and synapse loss. The two main neuropathological hallmarks are amyloid-b plaques and neurofibrillary tangles. In the brain of AD patients and in mouse models of AD several morphological and functional changes, such as microgliosis and astrogliosis around Ab plaques, as well as dendritic and synaptic alterations, are associated with these lesions. In this review, we will summarize the current literature on synapse loss in mouse models of AD and discuss current and prospective treatments for AD.

Keywords: Alzheimer's desease, amyloid plaques, glial cells, synapse loss, Microglia, Astrocytes

Received: 18 Sep 2018; Accepted: 20 Nov 2018.

Edited by:

Marie-Eve Tremblay, Laval University, Canada

Reviewed by:

Silvia Di Angelantonio, Sapienza University of Rome, Italy
Viola Nordström, German Cancer Research Center (DKFZ), Germany  

Copyright: © 2018 Meyer-Luehmann and Ziegler-Waldkirch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Melanie Meyer-Luehmann, University Hospital Freiburg, Freiburg, 79106, Baden-Württemberg, Germany, melmey2000@hotmail.com