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Front. Cell. Neurosci. | doi: 10.3389/fncel.2019.00127

The role of high mobility group box 1 in ischemic stroke

  • 1Renmin Hospital, Wuhan University, China
  • 2Zhujiang hospital, Southern Medical University, China

High-mobility group box 1 protein (HMGB1) is a novel, cytokine-like, and ubiquitous highly conserved nuclear protein that can be positively secreted by microglia or passively released by necrotic neurons. Ischemic stroke is a leading cause of death and disability worldwide, and the outcome is dependent on the amount of hypoxia-related neuronal death in the cerebral ischemic region. Acting as an endogenous danger-associated molecular pattern (DAMP) protein, HMGB1 mediates cerebral inflammation and brain injury, and participates in the pathogenesis of ischemic stroke. It is thought that HMGB1 signals via its presumed receptors, such as toll-like receptors (TLRs), matrix metalloproteinase (MMP) enzymes, and receptor for advanced glycation end products (RAGE) during ischemic stroke. In addition, the release of HMGB1 from the brain into the bloodstream influences peripheral immune cells. However, the role of HMGB1 in ischemic stroke may be more complex than this and has not yet been clarified. Here, we summarize and review the research into HMGB1 in ischemic stroke

Keywords: HMGB1 (high-mobility group box 1), Ischemia stroke, TLRs (Toll-like receptors), MMP (matrix metalloproteinase), RAGE (receptor for advanced glycation end products)

Received: 24 Sep 2018; Accepted: 14 Mar 2019.

Edited by:

Xiaohong Li, Institute for Basic Research in Developmental Disabilities (IBR), United States

Reviewed by:

Yu-Feng Wang, Harbin Medical University, China
Amit U. Joshi, Stanford University, United States  

Copyright: © 2019 Gu, Xiong, ye, zeng, jin and zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Lijuan Gu, Renmin Hospital, Wuhan University, Wuhan, China,
Prof. Xiaoxing Xiong, Renmin Hospital, Wuhan University, Wuhan, China,