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Front. Cell. Neurosci. | doi: 10.3389/fncel.2019.00383

On the involvement of BDNF signaling in memory reconsolidation

  • 1Federal University of Rio Grande do Norte, Brazil
  • 2Brain Institute, Federal University of Rio Grande do Norte, Brazil

When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state and, to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can be modified. Extensive literature implicates brain-derived neurotrophic factor (BDNF), a key regulator of synaptogenesis and synaptic plasticity, in the acquisition, consolidation and extinction of several memory types. However, the participation of BDNF in memory reconsolidation has been less studied. In this review, we discuss recent reports supporting the involvement of BDNF signaling in reactivation-induced memory updating.

Keywords: neurotrophin, Memory reconsolidation, TrkB, BDNF, memory retrieval

Received: 17 Apr 2019; Accepted: 06 Aug 2019.

Copyright: © 2019 Gonzalez, Radiske and Cammarota. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Martín Cammarota, Federal University of Rio Grande do Norte, Brain Institute, Natal, RN 59056-450, Brazil, martin.cammarota@neuro.ufrn.br