AUTHOR=Wang Qin , Banerjee Seema , So ChungHim , Qiu ChunTing , Sze YingHon , Lam Thomas Chuen , To Chi-Ho , Pan Feng 

TITLE=The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.664491

DOI=10.3389/fncel.2021.664491

ISSN=1662-5102

ABSTRACT=Low-dose atropine eye drops are had been applied to control myopia progression, especially in children. However, the impact of atropine on the retina is unclear. Mass spectrometry detected atropine in the retina after external ocular application. However, the application of atropine did not change the morphology and firing pattern of most retinal ganglion cells. Atropine unmasked inhibition to induce ON responses from certain OFF RGCs, possibly via the GABAergic pathway in the retina circuit. The results suggest that although atropine can reach the retina via the application of low-dose atropine eye drops, its presence did not change the spike frequency of the ON and OFF αRGCs. However, it may interfere with retinal signal processing in around one-fourth of OFF αRGCs.