Front. Cell. Neurosci. Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 1662-5102 Frontiers Media S.A. 10.3389/fncel.2021.782716 Cellular Neuroscience Correction Corrigendum: IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes Kim Yangsik 1 † Noh Young Woo 2 † Kim Kyungdeok 2 Yang Esther 3 Kim Hyun 3 Kim Eunjoon 2 4 * 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea 2Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea 3Department of Anatomy, College of Medicine, Korea University, Seoul, South Korea 4Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, South Korea

Edited and reviewed by: Lei Shi, Jinan University, China

 *Correspondence: Eunjoon Kim kime@kaist.ac.kr

This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience

†These authors have contributed equally to this work

 22 11 2021 2021 15 782716 24 09 2021 15 10 2021 Copyright © 2021 Kim, Noh, Kim, Yang, Kim and Kim. 2021 Kim, Noh, Kim, Yang, Kim and Kim

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 A Corrigendum on IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes by Kim, Y., Noh, Y. W., Kim, K., Yang, E., Kim, H., and Kim, E. (2020). Front. Cell Neurosci. 14:23. doi: 10.3389/fncel.2020.00023 autism synapse IRSp53 mPFC social interaction hyperactivity

In the original article, there was a mistake in Figure 3 as published. It was due to an inadvertent mistake in the quantification process. The new quantification indicates that there is no statistical difference in the NMDA/AMPA ratio between WT and IRSp53-KO mice; previous Figure 3C indicated a decrease in the mutant mice. The correct Figure 3 and legend appears below.

Emx1-Cre;Irsp53fl/fl and Viaat-Cre;Irsp53fl/fl mice show distinct changes in synaptic transmission and intrinsic excitability in medial prefrontal cortex (mPFC) pyramidal neurons. (A) Miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) in layer V pyramidal neurons in the prelimbic region of the mPFC in Emx1-Cre;Irsp53fl/fl and Viaat-Cre;Irsp53fl/fl mice (3 months; male). Note that the frequency of mEPSCs is significantly decreased in Emx1-Cre;Irsp53fl/fl mice. n = 13 neurons from three mice for f/f-mEPSC, 14, 3 for Emx1-mEPSC, 15, 3 for Viaat-mEPSC, 13, 3 for f/f-mIPSC, 15, 3 for Emx1-mIPSC, and 15, 3 for Viaat-mIPSC, *P < 0.05, ns, not significant, one-way ANOVA with Bonferroni's test. mEPSC frequency, F(2, 39) = 4.119; mEPSC amplitude, F(2, 39) = 0.342; mIPSC frequency, F(2, 40) = 2.012; mIPSC amplitude, F(2, 40) = 0.7806. (B) Intrinsic excitability in layer V pyramidal neurons in the prelimbic region of the mPFC in Emx1-Cre;Irsp53fl/fl and Viaat-Cre;Irsp53fl/fl mice (3 weeks; male). Note that intrinsic excitability is increased both in Emx1-Cre;Irsp53fl/fl and Viaat-Cre;Irsp53fl/fl mice. n = 13, 3 for f/f-firing frequency, 14, 3 for Emx1-firing frequency, 18, 3 for Viaat-firing frequency, 13, 3 for f/f-AP threshold, 14, 3 for Emx1-AP threshold, 18, 3 for Viaat-AP threshold, 13, 3 for f/f-input resistance, 14,3 for Emx1-input resistance, 18, 3 for Viaat-input resistance, *P < 0.05, ***P < 0.001; ns, not significant, one-way ANOVA with Bonferroni's test for AP threshold, two-way ANOVA with Bonferroni's test for firing frequency and input resistance. Sustained firing, interaction F(18, 420) = 3.165, current F(9, 420) = 61.89, genotype F(2, 420) = 56.73; action potential threshold, F(2, 42) = 16.14; input resistance, interaction F(6, 168) = 0.5088, current F(3, 168) = 60.88, genotype F(2, 168) = 11.33. (C) Normal ratio of evoked N-methyl-D-aspartate receptors (NMDAR)-EPSCs and AMPA receptor (AMPAR)-EPSCs in Emx1-Cre;Irsp53fl/fl layer V pyramidal neurons in the prelimbic region of the mPFC (2 months; male). n = 9 neurons for three mice for f/f, 11, 3 for Emx1, ns, not significant, Student's t-test, t = 0.2447, df = 18. (D) Increased ratio of evoked EPSCs and IPSCs in Emx1-Cre;Irsp53fl/fl layer V pyramidal neurons in the prelimbic region of the mPFC (2 months; male). n = 8 neurons for three mice for f/f, 8, 3 for Emx1, ***P < 0.001, Student's t-test, t = 5.019, df = 14. (E) Normal paired-pulse ratio in Emx1-Cre;Irsp53fl/fl layer V pyramidal neurons in the prelimbic region of the mPFC (2 months; male). n = 10 neurons for three mice for f/f, 9, 3 for Emx1, ns, not significant, two-way ANOVA with Bonferroni's test, interaction F(5, 85) = 0.6379, time F(5, 85) = 4.100, genotype F(1, 17) = 0.7348.

To reflect this change a correction has also been made to the Results, Emx1-Cre; Irsp53fl/fl and Viaat-Cre; Irsp53fl/fl Mice Show Distinct Changes in Synaptic Transmission and Intrinsic Excitability in mPFC Pyramidal Neurons, Second paragraph:

“When evoked synaptic transmission was measured, the ratio of NMDAR-mediated EPSCs and AMPA receptor (AMPAR)-mediated EPSCs was not altered in Emx1-Cre; Irsp53fl/fl layer V pyramidal neurons (Figure 3C). These results collectively suggest that Irsp53 deletion in glutamatergic neurons leads to reduced spontaneous excitatory but not inhibitory synaptic transmission, increased ratio of evoked EPSCs/IPSCs, and increased neuronal excitability without affecting evoked NMDAR-EPSC/AMPAR-EPSC ratio in layer V mPFC neurons.”

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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