Corrigendum: Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease

[This corrects the article DOI: 10.3389/fncel.2022.1045647.].

In the published article, there was an error in Figure 2 as published. The fourth column heading in Figure 2B was falsely written as "Spinal cord (G93A)." The correct column heading is "Spinal cord (G37R)." The corrected Figure 2 appears below.
In the published article, there was an error in Figure 3 as published. The Tnfrs12a values shown in Figure 3 are different from the data in 207 DEGs. The corrected Figure 3 appears below.
In the published article, there was an error in Figure 5 and text as published. The fold change of Abca1 in the spinal cords of SOD1 G85R mice shown in Figure 5 is 2.0, but this is a rounded value, which was 1.9779. Abca1 is not included in Table S5, which shows the list of 207 DEGs with more than strict 2-fold change, although the 1.9779-fold change of SOD1 G85R mice is statistically significant as well as the 3.3-fold changes in the spinal cords of SOD1 G37R and SOD1 G93A mice. The corrected Figure 5 appears below. A correction has been made to Results and discussion, Predicted pathomechanism among different cell types in SOD1-ALS mice related to TREM2, apolipoprotein E, and lipoproteins, Astrocytic changes. This sentence previously stated: "Abca1 was found in the 207 DEGs and was abundant in astrocytes and upregulated in P120 SOD1 G93A astrocytes." The corrected sentence appears below: "Abca1 was abundant in astrocytes and upregulated in P120 SOD1 G93A astrocytes." In the published article, there was an error in Supplementary  Table 5. Fold changes and p-value of three SOD1 mutant mice in Aspg, Casp12, Psmb8, Ctsd, Ctsc, Ctsh, Ctsl, Ctss, and Ctsz (214 th to 222 nd rows in uncollapsed sheet, columns H to M) were shifted one line by a handling error. The Supplementary Table 5 has been updated.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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. /fncel. . DEGs as an input. The first column shows the name of the PANTHER classification category. The second column shows the number of genes in the reference list that map to this particular PANTHER classification category. The total number of genes in the reference list is , . The third column shows the observed number of genes in our input list that map to this PANTHER classification category. The fourth column shows the expected value, which is the number of genes we would expect in our list for this PANTHER category, based on the reference list. The fifth column shows the fold enrichment, which is the ratio of the value of column (input: observed number) over that of column (expected number). The sixth column shows the raw p-values. The seventh column shows the q-value (adjusted p-value, reflecting the false discovery rate) as calculated by the Benjamini-Hochberg procedure. Cell adhesion molecule is in the parent category of integrin, so it is shown in the row below. Similarly, defense/immunity protein is the parent category of immunoglobulin receptor superfamily. Therefore, they are indicated with arrows. (B) Representative transcription factors in the DEGs. Three CCAAT/enhancer binding proteins and interferon regulatory factor are shown. (C) All of the DEGs were classified into cell types in which each gene is highly expressed; Unclassified are the genes that are not highly expressed in one particular cell type. MG, microglia.

FIGURE
Representative motor neuron-enriched genes, neuron-enriched genes, and oligodendrocyte-enriched genes in DEGs were analyzed using the integrated transcriptome and SOD G A cell-type transcriptome. The rd to th columns show the fold changes in each gene expression in SOD G A , SOD G R , and SOD G R mouse spinal cords compared to control samples, respectively. Genes with dark gray backgrounds in the rd to th columns that indicate fold changes (F.C.) are not included in the DEGs. The th to th columns show the integrated transcriptome. The th column shows the fold change in expression of each gene in P SOD G A microglia relative to control microglia. The th to th columns show the fold change in expression of each gene in SOD G A astrocytes (P or P ) relative to control astrocytes. MN, motor neurons; N, neurons; MG, microglia; OL, oligodendrocytes.