AUTHOR=Consalez G. Giacomo , Hawkes Richard TITLE=The compartmental restriction of cerebellar interneurons JOURNAL=Frontiers in Neural Circuits VOLUME=6 YEAR=2013 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2012.00123 DOI=10.3389/fncir.2012.00123 ISSN=1662-5110 ABSTRACT=

The Purkinje cells (PC's) of the cerebellar cortex are subdivided into multiple different molecular phenotypes that form an elaborate array of parasagittal stripes. This array serves as a scaffold around which afferent topography is organized. The ways in which cerebellar interneurons may be restricted by this scaffolding are less well-understood. This review begins with a brief survey of cerebellar topography. Next, it reviews the development of stripes in the cerebellum with a particular emphasis on the embryological origins of cerebellar interneurons. These data serve as a foundation to discuss the hypothesis that cerebellar compartment boundaries also restrict cerebellar interneurons, both excitatory [granule cells, unipolar brush cells (UBCs)] and inhibitory (e.g., Golgi cells, basket cells). Finally, it is proposed that the same PC scaffold that restricts afferent terminal fields to stripes may also act to organize cerebellar interneurons.