TY - JOUR AU - Kubota, Yoshiyuki AU - Karube, Fuyuki AU - Nomura, Masaki AU - Kawaguchi, Yasuo PY - 2016 M3 - Review TI - The Diversity of Cortical Inhibitory Synapses JO - Frontiers in Neural Circuits UR - https://www.frontiersin.org/articles/10.3389/fncir.2016.00027 VL - 10 SN - 1662-5110 N2 - The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subtypes engage in diverse inhibitory functions to produce the elaborate activity characteristic of the different cortical states. Each distinct non-pyramidal cell subtype has its own independent inhibitory function. Secondly, the inhibitory synapses innervate different neuronal domains, such as axons, spines, dendrites and soma, and their inhibitory postsynaptic potential (IPSP) size is not uniform. Thus, cortical inhibition is highly complex, with a wide variety of anatomical and physiological modes. Moreover, the functional significance of the various inhibitory synapse innervation styles and their unique structural dynamic behaviors differ from those of excitatory synapses. In this review, we summarize our current understanding of the inhibitory mechanisms of the cortical microcircuit. ER -