AUTHOR=Wagatsuma Nobuhiko , Potjans Tobias C., Diesmann Markus , Fukai Tomoki TITLE=Layer-Dependent Attentional Processing by Top-down Signals in a Visual Cortical Microcircuit Model JOURNAL=Frontiers in Computational Neuroscience VOLUME=5 YEAR=2011 URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2011.00031 DOI=10.3389/fncom.2011.00031 ISSN=1662-5188 ABSTRACT=

A vast amount of information about the external world continuously flows into the brain, whereas its capacity to process such information is limited. Attention enables the brain to allocate its resources of information processing to selected sensory inputs for reducing its computational load, and effects of attention have been extensively studied in visual information processing. However, how the microcircuit of the visual cortex processes attentional information from higher areas remains largely unknown. Here, we explore the complex interactions between visual inputs and an attentional signal in a computational model of the visual cortical microcircuit. Our model not only successfully accounts for previous experimental observations of attentional effects on visual neuronal responses, but also predicts contrasting differences in the attentional effects of top-down signals between cortical layers: attention to a preferred stimulus of a column enhances neuronal responses of layers 2/3 and 5, the output stations of cortical microcircuits, whereas attention suppresses neuronal responses of layer 4, the input station of cortical microcircuits. We demonstrate that the specific modulation pattern of layer-4 activity, which emerges from inter-laminar synaptic connections, is crucial for a rapid shift of attention to a currently unattended stimulus. Our results suggest that top-down signals act differently on different layers of the cortical microcircuit.