TY - JOUR AU - Tarnutzer, Alexander AU - Palla, Antonella AU - Marti, Sarah AU - Schuknecht, Bernhard AU - Straumann, Dominik PY - 2012 M3 - Original Research TI - Hypertrophy of the Inferior Olivary Nucleus Impacts Perception of Gravity JO - Frontiers in Neurology UR - https://www.frontiersin.org/articles/10.3389/fneur.2012.00079 VL - 3 SN - 1664-2295 N2 - Interruption of the dentato-olivary projections, interconnecting the dentate nucleus (DN) and the contralateral inferior olivary nucleus (ION), is predicted to interfere with the DN’ role in estimating direction of gravity. In a patient with pendular nystagmus due to hypertrophy of the ION secondary to predominantly right-sided ponto-mesencephalic hemorrhage, perceived vertical shifted from clockwise to counter-clockwise deviations within 4 months. We hypothesize that synchronized oscillations of ION neurons induce a loss of inhibitory control, leading to hyperactivity of the contralateral DN and, as a result, to perceived vertical roll–tilt to the side of the over-active DN. ER -