Determinants of Concurrent Motor and Language Recovery during Intensive Therapy in Chronic Stroke Patients: Four Single-Case Studies

Despite intensive research on mechanisms of recovery of function after stroke, surprisingly little is known about determinants of concurrent recovery of language and motor functions in single patients. The alternative hypotheses are that the two functions might either “fight for resources” or use the same mechanisms in the recovery process. Here, we present follow-up data of four exemplary patients with different base levels of motor and language abilities. We assessed functional scales and performed exact lesion analysis to examine the connection between lesion parameters and recovery potential in each domain. Results confirm that preservation of the corticospinal tracts (CSTs) is a neural predictor for good motor recovery while preservation of the arcuate fasciculus (AF) is important for a good language recovery. However, results further indicate that even patients with large lesions in CST, AF, and superior longitudinal fasciculus, respectively, are able to recover their motor/language abilities during intensive therapy. We further found some indicators of a facilitating interaction between motor and language recovery. Patients with positive improvement of motor skills after therapy also improved in language skills, while the patients with no motor improvements were not able to gain any language recovery.

Despite intensive research on mechanisms of recovery of function after stroke, surprisingly little is known about determinants of concurrent recovery of language and motor functions in single patients. The alternative hypotheses are that the two functions might either "fight for resources" or use the same mechanisms in the recovery process. Here, we present follow-up data of four exemplary patients with different base levels of motor and language abilities. We assessed functional scales and performed exact lesion analysis to examine the connection between lesion parameters and recovery potential in each domain. Results confirm that preservation of the corticospinal tracts (CSTs) is a neural predictor for good motor recovery while preservation of the arcuate fasciculus (AF) is important for a good language recovery. However, results further indicate that even patients with large lesions in CST, AF, and superior longitudinal fasciculus, respectively, are able to recover their motor/language abilities during intensive therapy. We further found some indicators of a facilitating interaction between motor and language recovery. Patients with positive improvement of motor skills after therapy also improved in language skills, while the patients with no motor improvements were not able to gain any language recovery.
Keywords: stroke, motor, language, hemiplegia, hemiparesis, aphasia, recovery introduction It is a common clinical observation that in patients with both initial hemiparesis and aphasia after stroke, motor and language recovery may take different courses. Interestingly, scientific research has primarily focused on the examination of the course of recovery regarding either motor or language abilities, but only few studies addressed both. Aphasia has even been a criterion for exclusion in several studies of motor recovery (1,2).
To our knowledge, there is only one multiple single-case study that addressed the issue of language recovery going parallel to a therapy of motor functions of the upper limb. Harnish et al. (3) examined five stroke patients during the course of 6 weeks of motor therapy. They assessed not only the recovery of motor functions of the upper limbs and functional motor reorganization but also changes in their language abilities. The authors report that in the three subjects showing the largest motor improvements they could also observe significant language improvements. In the individual fMRI measurements, where the patients had to tap the fingers of the paretic hand within the scope of their capacities, a shift of activation to the right hemisphere during the course of motor treatment could be observed in these three patients. Harnish et al. concluded that language changes seem to co-occur with motor changes after motor therapy. Anatomical analyses of the patients' lesions were not carried out.
The finding of Harnish et al. that motor recovery can foster language recovery is very interesting for the current state of discussion about common mechanisms in motor and language processing. Especially the theory of cognitive embodiment has gained broad attention and kindled a whole line of research. In the light of embodiment theory, cognitive functions like language are grounded in the sensorimotor experiences and to the underlying systems (4,5). For example, Hauk et al. (6) were able to show that language processing and comprehension activate motor regions, while Glenberg et al. (7) found that first-and secondgrade children who manipulate images of toys on a computer screen develop improved comprehension skills in reading -a comprehension benefit was evoked by the conduction of motor tasks. There are numerous imaging studies demonstrating activation of the sensorimotor systems by listening to language with motor content [for example, see Ref. (8,9)]. Recently anatomic correlates for common motor speech and motor (10) as well as language and motor processing (11) have been postulated on the basis of imaging data.
With the theoretical and experimental background that motor and language activity are not functionally independent, interdependencies regarding the course of recovery of these two domains can be assumed as well. These relations might result in two possible interactions between motor and language recovery processes: either competitive or additive effects may occur. Competitive rehabilitative interactions might be characterized by a "fight" for resources between the language and motor recovery capacities. In this case, a good motor recovery may limit or even prevent the course of language recovery and vice versa. The inverse assumption of an additive interaction between both domains during recovery implies that a positive course of motor recovery would influence language recovery positively, and vice versa. The results of Harnish et al. (3), which are in line with the findings concerning embodiment, seem to support the second hypothesis.
The identification of determinants of motor and language recovery after stroke is within the main stream of research on neurorehabilitation. There are several studies evaluating the role of lesion parameters as well as brain activation for complete or poor recovery for language and motor domain separately. We will briefly highlight the most relevant results in order to establish the backdrop for our study.
As to the motor domain, the lesion location is an important predictor for motor rehabilitation (12), whereas the size of the brain lesion seems to be no predictor for motor function recovery after stroke (12)(13)(14). Shelton and Reding (15) found that the probability of recovery of the upper limbs after stroke seems to diminish in dependence of the lesion location in the following order: cortex, corona radiata, and internal capsule. The dimension of impairment of the corticospinal tract (CST) is another indicator for good rehabilitation of hand motor function after stroke; severe damage of the CST has mainly been assessed in more severely affected patients (12)(13)(14)(15).
Similarly, in the language domain, lesion location may play an important role in sufficient language recovery. Meinzer et al. (16) found that language rehabilitation after intensive language therapy was correlated with the integrity of the left hippocampus and the surrounding white matter. Marchina et al. (17) were able to show that the extent of impairment of the left arcuate fasciculus (AF) is a predictor for language recovery. The global lesion size does not have an influence on language rehabilitation after stroke [e.g., see Ref. (16,18)].
Functional imaging has resulted in inconsistent results for both recovery of motor [e.g., see Ref. (19)(20)(21)(22)(23)] and language abilities [e.g., see Ref. (24)(25)(26)(27)(28)(29)]. The heterogeneity of the results in the language and motor domain can possibly be attributed to different methods and objectives that were used in previous studies as well as different types of strokes (e.g., subcortical vs. cortical). Therefore, it is hardly possible to combine the mentioned results of the two different domains for predicting recovery patterns in patients with concurrent impairments in both domains.
Therefore, neural correlates for simultaneous recovery in the language and motor domain after stroke remain unclear. The results of Harnish et al. (3), which were investigated through fMRI and behavioral measurements, give a first hint for an additive interaction between both domains during the course of rehabilitation. To our knowledge, there are no studies with the aim to explore lesion characteristics of different ways of concurrent motor and language recovery. Therefore, it remains unclear if an additive interaction between motor and language recovery processes through therapy can be linked to specific structural lesions in the brain.
The aim of the present study was to investigate systematically the determinants of language and motor recovery in four exemplary patients with different base levels of motor and language abilities. Alongside the clinical assessment of motor and language abilities, we focused on (1) the examination of lesion characteristics at pre-test and (2) possible interactions of motor and language recovery processes following the 7-week language and motor therapy phase (i.e., outcome at the post-test).
Apraxia of speech is a clinically known influence factor to the possibilities of improving language skills in aphasic patients. Furthermore, since anatomic correlates for common motor speech and motor processing have been described (10), motor speech could be considered a "link" between motor and language processing functions. Therefore, in addition to motor and language processing functions, we considered the phenomenon of apraxia of speech independently for the patients in our patient group. Since we aimed to discuss motor speech functions on a purely exploratory level, no precise hypotheses were formulated.
Over all, four hypotheses were formulated concerning both lesion characteristics and possible therapy-induced interactions: Regarding (1), lesion characteristics, the following hypotheses were addressed: (i) In line with current research (12-14, 16, 18), we assume that global lesion size is not a correlate for sufficient concurrent motor and language recovery. (ii) We expect that patients with smaller lesions in functionspecific white matter tracts for motor (CST) and language processing [AF, superior longitudinal fasciculus (SLF)] show good recovery potential in the particular domains as opposed to patients with extensive lesions to these tracts.
Regarding (2), possible interactions of motor and language recovery processes, our hypotheses are as follows: (iii) In line with Harnish et al. (3), we assume that patients with an increase in motor abilities after therapy phase will also show positive language recovery (i.e., an increase in language abilities at the post-test) and vice versa. This would indicate an additive interaction between motor and language domains during simultaneous motor and language therapy. (iv) Complementarily, we anticipate that patients who do not profit from motor therapy do not show an increase in language abilities at the post-test after therapy phase and vice versa.

Patients
Four patients suffering from subacute to chronic stroke with different base levels of motor and language skills at the beginning of the study (see Figure 1) were selected. The selection of patients with opposing base levels in motor and language skills was conducted in order to include previous individual recovery processes into the evaluation of the current recovery process. Clinical records documented that at the acute stage of the stroke, all patients were described as non-fluent to globally aphasic and had paresis of varying degrees, ranging from mild hemiparesis (4/5) to full hemiplegia. The different base levels resulted from the patients' individual recovery processes prior to the participation in the study. At the beginning of the study, language skills were classified as "good" (Base: L+) or "poor" (Base: L−) according to the patients' individual profile height in the language assessment of the Aachener Aphasie Test [AAT; (30) (see Table 1)]. Correspondingly, the classification of "good" vs. "poor" motor skills (M+ vs. M−) was based on the raw score of the Wolf Motor Function Test [WMFT (31), see Table 2]. This resulted in four possible baseline profiles: Base: M+/L+, M−/L+, M+/L−, and M−/L−, denoting good functions in both motor and language domains, the dissociations between the domains, and finally the combination of both severely impaired motor and language function at the pre-test of the study.
Apart from different performance patterns in the language and motor domain, the patients had to meet the following criteria for inclusion into the study: (1) general MRI compatibility, (2) native German speakers, (3) right-handed according to the Edinburgh Inventory of Handedness [Laterality coefficient ≥80; (32)], (4) normal or corrected-to-normal vision, (5) no hearing loss, (6) no pregnancy, (7) single stroke in the left hemisphere, (8) subacute or chronic stage of stroke (at least 6 weeks post onset), (9) clinically diagnosed aphasia or residual symptoms of aphasia and clinically diagnosed hemiparesis, and (10) no history of dementia or other CNS or psychiatric diseases.
The patients were recruited from the Aphasia Rehabilitation Ward of the Neurological Clinic, Uniklinik RWTH Aachen. Informed written consent for participating in the study was obtained from each patient prior to the participation in the study. The study was approved by the local ethics committee and conducted according to the Declaration of Helsinki. Patient characteristics are displayed in Figure 1.

research Design
All patients were recruited during their 7-week stay at the Aphasia Rehabilitation Ward of the Department of Neurology, Uniklinik RWTH Aachen. A pre-post test design was used to assess both motor and language abilities prior and after the 7-week therapy phase. The pre-test took place during the first week of the treatment. Deficits were quantified using standardized assessment tests and applied by trained personnel (speech and language therapists, physiotherapists, and neurologists). Structural MRI scans were conducted in the first week of the patients' stay at the hospital. The post-test took place during the seventh (i.e., last) week of the stay at the Aphasia Rehabilitation Ward. Again, the functional language and motor scales were used to evaluate patients' development during the intensive treatment. MRI measurements were not repeated. Between pre-and post-test, the patients participated in 7 weeks of motor and language therapy (for an overview of the research design, see Figure 2).

clinical examinations
The following tests were applied:

Functional Motor Scales
The Wolf Motor Function Test [WMFT (31)] was applied to evaluate the quality and duration of the patients' arm and hand movements. In addition, the Dynamic Gait Index [DGI (34)] was conducted in order to assess gait and balance.

Additional Scale
Three subtests from the "Aachener Materialien zur Diagnostik Neurogener Sprechstörungen" [AMDNS (35)] were used in order to screen for neurogenic speech disorders: "duration of phonation, " "variability of speech intensity, " and "articulatory diadochokinesis. " These subtests were used to control the influence of the patients' motor speech function on motor and language ability and recovery. In addition, subtest "Articulation" (spontaneous speech) of the AAT was considered separately, since it is specially related to motor speech functions.

Analysis of Behavioral Data
The single-case characteristics of our study put some restraints on the statistical tests that are available. For the AAT, significant improvements and deteriorations were differentiated. To test for significant changes in the patient's performance between pre-and post-test, the computer program "AATP" (36) was employed. This program automatically calculates significant changes using the psychometric single-case diagnosis (37) with p < 0.1, an alphalevel that is common for single cases. In reference to LEMO, significant changes between pre-and post-test were calculated

analysis of imaging Data
All data were analyzed on an individual subject basis. For the analysis of lesions, all lesions were marked within the FLAIR image using MRIcron (38). Afterwards, the lesion maps were normalized via FLIRT (39)  Lesions of the patients were analyzed according to their localization in the following cortical and subcortical structures: frontal lobe, parietal lobe, temporal lobe, occipital lobe, insula, putamen, thalamus, and caudate. Concerning white matter tracts, the lesion analysis procedure previously described was conducted for the CSTs, SLF and AF. All fiber tracts were included due to their previously described role in motor and language processing.

Behavioral Data
The patients' overall behavioral outcome (changes of performance after the 7-week therapy phase) in the functional scales showed heterogeneous results both for motor and language assessments (see Tables 1 and 2; Tables S1-S3 in Supplementary Material).

additional scale
Motor speech abilities (AMDNS) showed heterogeneous results with both notable improvements and deteriorations across all patients' performances. However, none of the measured changes occurred on a significant level. An overview of the results in these tests is given in Table 3 Table 4)].

synoptical analysis of Behavioral and lesion-related Data
As shown in Tables 5 and 6, all patients had lesions in the frontal and parietal lobe, as well as white matter tract injury in the SLF and AF (see also Figures 3 and 4). Concerning further cortical and subcortical structures, patients did not show a homogeneous pattern of their lesions. In the following tables, we demonstrate an overview of the patients' recovery outcome following the 7-week therapy phase together with the patients' lesion characteristics in TaBle 4 | results of the patients in the subtest "articulation" (aaT; degree of impairment).   cortical and subcortical ( Table 5) as well as white matter tract areas ( Table 6).

Discussion
The present study explored if there are determinants for concurrent motor and language recovery during intensive therapy in four exemplary chronic stroke patients with different base levels of language and motor abilities. In particular, we examined if (1) concerning lesion characteristics (i) the global lesion size is a correlate of sufficient concurrent motor and language recovery and if (ii) the extent of damage of the function-specific white matter tracts for motor and language is predictive for the recovery potential in the respective domains.
In the further analysis of (2) possible interactions of motor and language recovery processes, we investigated if (iii) an additive interaction between motor and language domains during simultaneous motor and language therapy occurs and if (iv) there will be a lack of interaction between both domains when there is no recovery progress in at least one domain.
The four patients had different motor and language base levels and were systematically examined in this study to evaluate the relation of their therapy outcome in both domains (i.e., recovery process that was measured from pre-to post-test) and lesion parameters. To explore predictors for (iii) concurrent motor and language recovery, various functional scales in the motor and language domain and also in the motor speech domain were applied. Concerning the lesion analysis, cortical and subcortical lesion characteristics as well as white matter tract damage were explored.
One major finding of this study is that we could detect some indicators for an additive behavior of motor and language recovery. It seems that motor and language recovery co-occur in a sense that motor recovery facilitates the possibility of a positive therapy-induced language recovery. In addition, lesion size per se is not determining a sufficient motor and language recovery. However, the specific lesion areas play an important role for a sufficient recovery. Another main finding was that large damage in important fiber structures for motor or language processing allows no prediction about the recovery of the fiber-induced function at a single subject level.

Global Lesion Size
Considering the global lesion size in our four patients, Patient 3 (Base: M+/L−) was the only participant who was able to improve significantly in both motor and language functions at the post-test. In addition, this patient had the second largest overall lesion size. In comparison, Patient 2 (Base: M−/L+), the patient showing the   Tables 5 and 6). This difference could be attributed to the fact that the measureable extent of the lesion in Patient 2 is primarily caused by the location of the lesion at the level of the primary motor cortex, whereas Patient 3's smaller lesion mainly affects the part of the pyramidal tract further down in the corona radiata (see Figure 4). It is possible that this specificity of the anatomical lesion site in Patient 3 leads to a higher amount of damage to fibers that are relevant to motor recovery.
In summary, among our patient group, Patient 1 (Base: M+/L+) showed no lesion of the CST and no therapy-induced improvement due to ceiling effects and an already high level of motor functions at the pre-test. Patient 2 (Base: M+/L−) showed an extensive overall lesion, however, damage was more related to cortical structures than to lesions in the CST. This patient showed good recovery potential with improvements in both motor function tests. In comparison, Patient 3 (Base: M+/L−) showed a smaller lesion, however, he only recovered to a smaller degree than Patient 2 (Base: M−/L+). His lesion location in the corona radiata probably led to a reduction in recovery potential. Last, Patient 4 (Base: M−/L−) with the most extensive lesion of the CST was not able to improve in motor therapy at all. This result is supportive to the finding that strategic lesion location, rather than lesion volume, is an important determinant to recovery potential [e.g., see Ref. (15)].
Concerning the lesion of the AF, similar results could be found. Patient 2 (Base: M−/L+) who showed the smallest lesion of the AF did not show therapy-induced language improvement at the post-test, as well as Patient 1 (Base: M+/L+) who presented with the second smallest lesion. Patient 4 (Base: M−/L−) who showed the most spacious lesion of the AF was also not able to profit significantly from intensive therapy. Only Patient 3 (Base: M+/L−) was able to improve strongly in both language scales, although he showed the second largest lesion of the AF.
These findings seemingly point toward the assumption that the specific lesion size of the CST and/or AF does not directly influence the outcome of motor and/or language recovery. However, we feel that this assumption would be too shortsighted since at this point, the individual base levels, i.e., the level of motor and language skills that the patients presented with at the pre-test, need to be considered: regarding the lesion of the CST, we pointed out that Patient 1 (Base: M+/L+) did not show motor recovery although he did not have any lesion of the CST. However, Patient 1 already showed a comparatively high level of motor skills at the pre-test (see Table 2), leaving him with only small possibilities for significant improvements at the post-test. The same holds for Patient 2 (Base: M−/L+) regarding the extent of the AF lesion. As described, Patient 2 showed the smallest AF lesion of all patients but did not show language recovery. This could be attributed to possible ceiling effects. However, even after eliminating those two patients with possible ceiling effects from our considerations, in our patient group still neither the patient with the (then) smallest CST lesion [Patient 3 (Base: M+/L−)] nor the patient with the (then) smallest AF lesion [Patient 1 (M+/L+)] are the patients showing most motor and language recovery, respectively. This observation points strongly toward the conclusion, that even patients with large lesion of the CST/AF are able to recover motor/language abilities during intensive therapy.

interactions of Motor and language recovery Processes
Based on the results that were published by Harnish et al. (3), we assumed that the patients with an increase in motor abilities after the 7-week therapy phase would show positive language recovery (i.e., an increase in language abilities at the post-test), indicating that an additive interaction between motor and language domains during simultaneous motor and language therapy occurs. We also anticipated that patients who do not profit from motor therapy do not show an increase in language abilities at the post-test after therapy phase and vice versa. Regarding the data of our four patients, two of our patients, namely Patient 2 (Base: M−/L+) and Patient 3 (Base: M+/L−), were able to profit from motor therapy, leading to a significant improvement of motor functions at the post-test. Of these two patients, Patient 2 (Base: M−/L+) did not show improvements in the language domain while Patient 3 (Base: M+/L−) was a strong responder to language therapy also (see Tables 5 and 6). However, Patient 2 (Base: M−/L+) already showed a comparatively high level of language skills at the pre-test with a mean profile height of 72.5 in the AAT (see Table 1) as well as even the maximum possible raw scores at LeMo, indicating only mild residual symptoms of aphasia even at the beginning of the therapy phase.
As to Patient 1 (Base: M+/L+) and Patient 4 (Base: M−/L−), none of them were able to improve motor function skills and, in addition, none of them were able to profit from language therapy. Of the two patients, Patient 1 (Base: M+/L+) already showed a relatively high language profile at the pre-test, however, with a mean profile height of 57.9 in the AAT, he clearly could have improved significantly in that scale. Additionally, the raw scores indicate that significant improvement of the subtest "Finding Rhymes" (LeMo) would also have been possible (see Table 1). Therefore, the existence of ceiling effects in this patient can be excluded and the lack of positive therapy outcome has to be considered as a "real" effect.
In none of our four patients improvements in the motor or the language domains were bound to measurable deteriorations in the other domain. This lack of dissociation between the recovery processes of the two domains hints toward the assumption that a "fight for resources" could not be observed in our patient group.
In conclusion, only one patient with a positive response to motor therapy [Patient 3 (Base: M+/L−)] was able to improve significantly in language functions at the pre-test, whereas Patient 2 (Base: M−/L+), who also improved significantly in motor functions, could not have achieved measurable improvements due to ceiling effects in the language domain but did show numerical improvements of language skills. The evident motor recovery in the case of Patient 3 (Base: M+/L−) might have been a facilitating factor for a good response to language therapy. The two patients who could not benefit from the intensive motor therapy program [Patient 1 (Base: M+/L+) and Patient 4 (Base: M−/L−)] could also not improve significantly concerning language skills. Therefore, we assume that these results are suggestive of a positive interaction operating between motor and language domains during recovery in the sense that a positive therapy-induced motor recovery is a prerequisite to the possibility of recovering language skills through language therapy. This finding is in accordance with Harnish et al. (3). Regarding the oppositional outcome (positive language therapy outcome leading to improved motor outcome), no such interactions could be observed, therefore, due to our small sample size, it is not possible to formulate a conclusion concerning the possibility of contrary recovery dynamics.

apraxia of speech
Interestingly, dissociations in the recovery of apraxia of speech became apparent in the additional functional Scale AMDNS and in the subtest "articulation" of the AAT.
Only Patient 1 (Base: M+/L+), who had the smallest amount of lesioned voxels in the frontal lobe (see Table 5), was able to improve notably in "articulatory diadochokinesis" and "duration of phonation" (AMDNS) and showed a notable improvement in the communication parameter "articulation" (AAT; see Tables 3 and 4 Table 5). The insula is associated with articulatory coding/motor programing and motor control [e.g., see Ref. (42,43)] and its left precentral gyrus forms also an anatomical correlate for the development of apraxia of speech (44,45). Therefore, preservation of the insula appears to be a necessary, but not exclusive predictor for motor speech recovery. Lesions in other cortical or subcortical regions may also play a role for developing recovery potential in motor speech coordination. This assumption would be in accordance with the findings of Ogar et al. (45). They pointed out that patients showing a severe apraxia of speech had larger lesions in neighboring regions like Broca's area or basal ganglia. To conclude, the described literature and our findings suggest that the overall amount of lesioned voxels in the frontal lobe per se is able to predict motor speech recovery in our sample of patients. This finding has to be tested in a larger number of patients and, in addition, distinctive subcortical parts of the frontal lobe like insular or basal ganglia should be analyzed precisely in reference to their predictive value for recovery.

limitations
The present multiple case study provides a new approach in analyzing concurrent motor and language recovery as well as the interaction behavior between these domains during recovery. On the one hand, our findings provide some first indictors, given the fundamental research gap in this field. On the other hand, the data in this study are of limited generalizability as only single cases were examined. In addition, a more specific analysis of specific brain areas is needed. It was also not possible to control the time of onset/duration of aphasia and motor dysfunction in the patients. This is a variable of potential influence due to different restitution processes in different time intervals after stroke [e.g., restitution in the early subacute vs. chronic stage of aphasia; see Ref. (46)]. A group study would be necessary to elucidate if these first results are transferable to a larger sample of subjects.

conclusion and Perspectives
To conclude, we show that primarily the strategic location of the lesion is a determinant of functional recovery in the motor and language domain. Another main finding was that large damage to important white matter structures for motor or language processing is not a single predictive factor for the recovery of the affected function. Regarding motor speech, the extent of damage to the frontal lobe (especially insula) seems to be a neural correlate for a good motor speech (apraxia of speech) recovery. Poor motor speech abilities, often associated with an apraxia of speech, play a special role in the recovery of language skills and are distinguished by large frontal lesions.
With respect to the interaction of the motor and language domain during recovery, first hints for additive effects were found. Those patients with good base levels in motor skills improved in language abilities. Therefore, motor and language improvement seem to co-occur, as stated before by Harnish and colleagues (3), rather than to compete for recovery resources.
Concerning the mechanisms of recovery, we were not able to find evidence for a "fight for resources, " since motor or language recovery was not associated with a loss of abilities in the other domain, respectively. But it was clearly visible that there is no prospect of recovery in the language domain if there are no resources and abilities available in the motor domain. This is indicative for an additive, synergetic recovery mechanism as described by Harnish and colleagues (3).
A further important finding was that the characteristics of the lesion (specific area, overall size) are no obligatory determinant or predictor for the success of motor or language therapy. We could show that a patient with large CST damage exhibited positive motor recovery while a patient with large AF/SLF damage improved well in the language testing.
In this study, only single cases were analyzed. A larger group study will investigate recovery mechanisms and correlates supported by a higher statistical power as well as additional fMRI measurements. The results, together with the findings in this