TY - JOUR AU - Di Lorenzo, Cherubino AU - Coppola, Gianluca AU - Di Lenola, Davide AU - Evangelista, Maurizio AU - Sirianni, Giulio AU - Rossi, Paolo AU - Di Lorenzo, Giorgio AU - Serrao, Mariano AU - Pierelli, Francesco PY - 2018 M3 - Original Research TI - Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial JO - Frontiers in Neurology UR - https://www.frontiersin.org/articles/10.3389/fneur.2018.00064 VL - 9 SN - 1664-2295 N2 - IntroductionDrug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.AimHere, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients.Materials and methodsEighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction).ResultsOf the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61).ConclusionWe observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT03244735. ER -